Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?
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Issue Date
2008-05
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Oxidative damage to DNA is regarded as an important step in carcinogenesis. These lesions may arise as a consequence of exposure to xenobiotics, but are also generated as a consequence of endogenous generation of oxidizing compounds. Measurements of oxidative damage to guanines, such as 8-oxo-7, 8-dihydroguanine (8-oxodG) are increasingly being regarded as reliable biomarkers of oxidative stress and they may have a predictive value of cancer risk, although this needs to be established independently in several cohort studies. A survey of intervention studies of the ingestion of antioxidant-containing foods or tablets of antioxidants indicate that about one-third of the studies reported a protective effect in terms of lower levels of oxidative damage to DNA in white blood cells or decreased urinary excretion of 8-oxodG. Although firm conclusions cannot be reached, there appears to be links between ingestion of antioxidants, oxidative damage to DNA, and risk of cancer.Citation
Eur. J. Nutr. 2008, 47 Suppl 2:19-28Journal
European journal of nutritionPubMed ID
18458832Additional Links
http://www.springerlink.com/content/b8711066866343k5/Type
ArticleLanguage
enISSN
1436-6207Sponsors
This review was written as a part of the research integration in the Workpackage “Mechanisms of modulation of cancer by dietary factors” in the NoE Environmental Cancer risk, Nutrition and Individual Susceptibility (ECNIS, no. 513943; www.ecnis.org).”ae974a485f413a2113503eed53cd6c53
10.1007/s00394-008-2004-0
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