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    Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?

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    Authors
    Loft, Steffen
    Moller, Peter
    Cooke, Marcus S.
    Rozalski, Rafal
    Olinski, Ryszard
    Issue Date
    2008-05
    
    Metadata
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    Abstract
    Oxidative damage to DNA is regarded as an important step in carcinogenesis. These lesions may arise as a consequence of exposure to xenobiotics, but are also generated as a consequence of endogenous generation of oxidizing compounds. Measurements of oxidative damage to guanines, such as 8-oxo-7, 8-dihydroguanine (8-oxodG) are increasingly being regarded as reliable biomarkers of oxidative stress and they may have a predictive value of cancer risk, although this needs to be established independently in several cohort studies. A survey of intervention studies of the ingestion of antioxidant-containing foods or tablets of antioxidants indicate that about one-third of the studies reported a protective effect in terms of lower levels of oxidative damage to DNA in white blood cells or decreased urinary excretion of 8-oxodG. Although firm conclusions cannot be reached, there appears to be links between ingestion of antioxidants, oxidative damage to DNA, and risk of cancer.
    Citation
    Eur. J. Nutr. 2008, 47 Suppl 2:19-28
    Journal
    European journal of nutrition
    URI
    http://hdl.handle.net/10146/77963
    DOI
    10.1007/s00394-008-2004-0
    PubMed ID
    18458832
    Additional Links
    http://www.springerlink.com/content/b8711066866343k5/
    Type
    Article
    Language
    en
    ISSN
    1436-6207
    Sponsors
    This review was written as a part of the research integration in the Workpackage “Mechanisms of modulation of cancer by dietary factors” in the NoE Environmental Cancer risk, Nutrition and Individual Susceptibility (ECNIS, no. 513943; www.ecnis.org).”
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00394-008-2004-0
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