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    Sensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposure.

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    Authors
    de Vocht, Frank
    Burstyn, Igor
    Ferro, Gilles
    Olsson, Ann
    Hashibe, Mia
    Kromhout, Hans
    Boffetta, Paolo
    Issue Date
    2009-05
    
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    Abstract
    PURPOSE: A multi-centre IARC-coordinated European cohort study provided evidence of an association between lung cancer risk and bitumen fume exposure. Sensitivity analyses were conducted to assess whether these associations were robust to assumptions in the exposure assessment for which support could not be obtained due to lack of either measurements or direct observations. METHODS: New exposure estimates were generated by changing assumptions on exposure levels, specific tasks, lags, and coal tar use. Subsequently, Poisson regression models estimated relative risks (RRs); change in fit of models was evaluated. RESULTS: The influence of these assumptions was minimal, with log-likelihood deviations between -5.0 and 4.7% and similar patterns in dose-dependent increases of lung cancer risk. In the highest exposure categories, point estimates of RRs ranged 2.07-2.83 for average, and 1.22-2.23 for cumulative exposure. CONCLUSIONS: The small increase in lung cancer risk associated with bitumen fume exposure depends only to a limited extent on the subjective judgments made in the exposure assessment for this cohort.
    Citation
    Int. Arch. Occup. Environ. Health 2009, 82 (6):723-733
    Journal
    International archives of occupational and environmental health
    URI
    http://hdl.handle.net/10146/76454
    DOI
    10.1007/s00420-008-0373-6
    PubMed ID
    18956211
    Additional Links
    http://www.springerlink.com/content/e0728722ht844630/
    Type
    Article
    Language
    en
    ISSN
    1432-1246
    Sponsors
    This study was sponsored by a training fellowship grant from the European Union Sixth Framework Programme Network of Excellence on Environmental Cancer risk, Nutrition and Individual Susceptibility (ECNIS) (FOOD-CT-2005-513 943). The international component of the study was supported by share cost contracts from the European Commission (grant No. BMH4-CT95-1100) and EAPA, Eurobitume, and CONCAWE.
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00420-008-0373-6
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