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dc.contributor.authorde Kok, Theo M.
dc.contributor.authorvan Breda, Simone G.
dc.contributor.authorManson, Margaret M.
dc.date.accessioned2009-08-06T07:54:06Z
dc.date.available2009-08-06T07:54:06Z
dc.date.issued2008-05
dc.identifier.citationEur. J. Nutr. 2008, 47 Suppl 2:51-59en
dc.identifier.issn1436-6207
dc.identifier.pmid18458834
dc.identifier.doi10.1007/s00394-008-2006-y
dc.identifier.urihttp://hdl.handle.net/10146/76433
dc.description.abstractConsumption of fruits and vegetables has generally been associated with a decrease in cancer incidence and cardiovascular disease. Over the years, numerous bioactive compounds have been identified that contribute to these beneficial health effects. More recently, evidence is emerging that specific combinations of phytochemicals may be far more effective in protecting against cancer than isolated compounds. Combinatorial effects have been observed where any one of the single agents is inactive. Apart from interactions among dietary micronutrients, drug-phytochemical interactions have also been observed, indicating possibilities for improved cancer therapeutic strategies. Our understanding of the molecular mechanisms underlying such synergistic effects is still limited, but it appears that different combinations of complementary modes of actions are involved. In this review, we discuss the molecular mechanisms that are likely to be involved in cancer chemoprevention and summarize the most important findings of those studies that report synergistic chemopreventive effects of dietary compounds.
dc.language.isoenen
dc.relation.urlhttp://www.springerlink.com/content/t07k43lv73323137/en
dc.subjectchemopreventionen
dc.subjectphytochemicalsen
dc.subjectsynergistic effectsen
dc.subjectpolyphenolsen
dc.subjectvegetablesen
dc.subject.meshAnticarcinogenic Agents
dc.subject.meshChemoprevention
dc.subject.meshDrug Synergism
dc.subject.meshFlavonoids
dc.subject.meshFruit
dc.subject.meshHumans
dc.subject.meshNeoplasms
dc.subject.meshPhenols
dc.subject.meshPlant Extracts
dc.subject.meshVegetables
dc.titleMechanisms of combined action of different chemopreventive dietary compounds: a review.en
dc.typeArticleen
dc.identifier.journalEuropean journal of nutritionen
html.description.abstractConsumption of fruits and vegetables has generally been associated with a decrease in cancer incidence and cardiovascular disease. Over the years, numerous bioactive compounds have been identified that contribute to these beneficial health effects. More recently, evidence is emerging that specific combinations of phytochemicals may be far more effective in protecting against cancer than isolated compounds. Combinatorial effects have been observed where any one of the single agents is inactive. Apart from interactions among dietary micronutrients, drug-phytochemical interactions have also been observed, indicating possibilities for improved cancer therapeutic strategies. Our understanding of the molecular mechanisms underlying such synergistic effects is still limited, but it appears that different combinations of complementary modes of actions are involved. In this review, we discuss the molecular mechanisms that are likely to be involved in cancer chemoprevention and summarize the most important findings of those studies that report synergistic chemopreventive effects of dietary compounds.


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