Show simple item record

dc.contributor.authorCrusius, J.B.A.
dc.contributor.authorCanzian, F.
dc.contributor.authorCapella, G.
dc.contributor.authorPena, A .S.
dc.contributor.authorPera, G.
dc.contributor.authorSala, N.
dc.contributor.authorAgudo, A..
dc.contributor.authorRico, F.
dc.contributor.authorDel Giudice, G.
dc.contributor.authorPalli, D.
dc.contributor.authorPlebani, M.
dc.contributor.authorBoeing, H.
dc.contributor.authorBueno-de-Mesquita, H.B.
dc.contributor.authorCarneiro, F.
dc.contributor.authorPala, V.
dc.contributor.authorSave, V.E.
dc.contributor.authorVineis, P.
dc.contributor.authorTumino, R.
dc.contributor.authorPanico, S.
dc.contributor.authorBerglund, G.
dc.contributor.authorManjer, J.
dc.contributor.authorStenling, R.
dc.contributor.authorHallmans, G.
dc.contributor.authorMartinez, C.
dc.contributor.authorDorronsoro, M.
dc.contributor.authorBarricarte, A.
dc.contributor.authorNavarro, C.
dc.contributor.authorQuiros, J.R.
dc.contributor.authorAllen, N.
dc.contributor.authorKey, T.J.
dc.contributor.authorBinghan, S
dc.contributor.authorCaldas, C..
dc.contributor.authorLinseisen, J.
dc.contributor.authorKaaks, R.
dc.contributor.authorOvervad, K.
dc.contributor.authorTjonneland, A.
dc.contributor.authorBchner, F.C.
dc.contributor.authorPeeters, P.H.M.
dc.contributor.authorNumans, M.E.
dc.contributor.authorClavel-Chapelon, F.
dc.contributor.authorTrichopoulou, A.
dc.contributor.authorLund, E
dc.contributor.authorJenab, M.
dc.contributor.authorRinaldi, S..
dc.contributor.authorFerrari, P.
dc.contributor.authorRiboli, E.
dc.contributor.authorGonzáalez, C.A.
dc.date.accessioned2009-08-05T07:54:25Z
dc.date.available2009-08-05T07:54:25Z
dc.date.issued2008-11
dc.identifier.citationAnn. Oncol. 2008, 19 (11):1894-1902en
dc.identifier.issn1569-8041
dc.identifier.pmid18628242
dc.identifier.doi10.1093/annonc/mdn400
dc.identifier.urihttp://hdl.handle.net/10146/76316
dc.description.abstractBACKGROUND: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. PATIENTS AND METHODS: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL)1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin alpha and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. RESULTS: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF -487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). CONCLUSION: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.
dc.description.sponsorshipSome authors are partners of ECNIS, a network of excellence of the EC (FP6 contract 513943).en
dc.language.isoenen
dc.relation.urlhttp://annonc.oxfordjournals.org/cgi/content/full/19/11/1894en
dc.subjectAdenocarcinomaen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectInterleukinsen
dc.subjectNutritional Statusen
dc.subjectStomach Neoplasmsen
dc.subjectTumor Necrosis Factor-alphaen
dc.subject.meshAdenocarcinoma
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCase-Control Studies
dc.subject.meshCytokines
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshGenotype
dc.subject.meshHaplotypes
dc.subject.meshHumans
dc.subject.meshInterleukins
dc.subject.meshLymphotoxin-alpha
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNutritional Status
dc.subject.meshPolymorphism, Genetic
dc.subject.meshProspective Studies
dc.subject.meshStomach Neoplasms
dc.subject.meshTumor Necrosis Factor-alpha
dc.titleCytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST).en
dc.typeArticleen
dc.identifier.journalAnnals of oncology : official journal of the European Society for Medical Oncology / ESMOen
html.description.abstractBACKGROUND: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. PATIENTS AND METHODS: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL)1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin alpha and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. RESULTS: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF -487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). CONCLUSION: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.


This item appears in the following Collection(s)

  • Articles
    Articles of researchers from ECNIS Network of Excellence

Show simple item record