Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractClinical and subclinical human papillomavirus (HPV) infections are the most common sexually transmitted infections in the world, and most sexually-active individuals are likely to be exposed to HPV infection during their lifetimes. More than 40 genotypes of HPV infect the epithelial lining of the anogenital tract and other mucosal areas of the body; of these, 13-18 types are considered to be high-oncogenic risk HPV types (HR-HPV). Persistent infection with HR-HPVs is now unequivocally established as a necessary cause of cervical cancer and is likely to be responsible for a substantial proportion of other anogenital neoplasms and upper aero-digestive tract cancers. Low oncogenic risk HPV types (LR-HPV) are also responsible for considerable morbidity as the cause of genital warts. Youth and certain sexual characteristics are key risk factors for HPV acquisition and persistence of HPV infection, but other mediating factors include smoking, oral contraceptive (OC) use, other STIs (e.g. chlamydia, herpes simplex virus), chronic inflammation, immunosuppressive conditions including HIV infection, parity, dietary factors, and polymorphisms in the human leukocyte antigen system. Not surprisingly, these factors are also established or candidate cofactors identified in epidemiologic studies of cervical cancer. HPV transmissibility and molecular events in HPV-induced carcinogenesis have been the focus of recent multidisciplinary epidemiologic studies. This shift in research focus coincides with a shift in cancer prevention techniques towards immunization with HPV vaccines and HPV testing of precancerous lesions.
CitationVaccine 2006, 24 Suppl 1:S1-15
DescriptionKEYWORDS - CLASSIFICATION: cancer epidemiology;complications;Canada;epidemiology;Evaluation;Female;Genital Diseases,Female;Humans;Incidence;lifestyle modulation of cancer & cancer biomarkers;Papillomaviridae;Papillomavirus Infections;Risk Factors;Uterine Cervical Neoplasms;virology.
- Epidemiology of mucosal human papillomavirus infection and associated diseases.
- Authors: Trottier H, Burchell AN
- Issue date: 2009
- New concepts on risk factors of HPV and novel screening strategies for cervical cancer precursors.
- Authors: Syrjänen K
- Issue date: 2008
- Natural history and epidemiology of HPV infection and cervical cancer.
- Authors: Castellsagué X
- Issue date: 2008 Sep
- Human papillomavirus infection: epidemiology and pathophysiology.
- Authors: Steben M, Duarte-Franco E
- Issue date: 2007 Nov
- Epidemiology of anogenital warts and cancer.
- Authors: Franco EL
- Issue date: 1996 Sep