Quinone reductase induction as a biomarker for cancer chemoprevention.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractChemoprevention involves the use of natural or synthetic substances to reduce the risk of developing cancer. Strategies for protecting cells from initiation events include decreasing metabolic enzymes responsible for generating reactive species (phase I enzymes) while increasing phase II enzymes that can deactivate radicals and electrophiles known to intercede in normal cellular processes. Reduction of electrophilic quinones by quinone reductase is an important detoxification pathway. Following evaluation of approximately 3000 plant and marine organism extracts, the number characterized as "active" was established in the range of 12% of the total, and over 60 active compounds have been isolated as quinone reductase inducers. One of them, isoliquiritigenin (1), isolated from tonka bean, was shown to be a monofunctional inducer by having similar quinone reductase inducing ability in wild-type Hepa 1c1c7 cells and two mutant cell lines. To further investigate the mechanism of induction, HepG2 human hepatoma cells stably transfected with ARE-luciferase plasmid were used. Isoliquiritigenin (1) significantly induced the luciferase activity in a dose-dependent manner. On the basis of these results, a full-term cancer chemoprevention study was conducted with 7,12-dimethylbenz[a]anthracene (DMBA)-treated female Sprague-Dawley rats. Dietary administration of 1 increased tumor latency. Based on these promising preliminary results, additional mechanistic studies are underway, as well as full-term carcinogenesis studies with chronic administration schedules.
CitationQuinone reductase induction as a biomarker for cancer chemoprevention. 2006, 69 (3):460-3 J. Nat. Prod.
JournalJournal of natural products
DescriptionKEYWORDS CLASSIFICATION: analogs & derivatives;Animals;Anticarcinogenic Agents;biosynthesis;Biological Markers;chemistry;Chalcone;Chalcones;Chemoprevention;dietary modulation of cancer & cancer biomarkers;dietary modulation of carcinogenesis-related pathways;Disease Models,Animal;Enzyme Induction;metabolism;Molecular Structure;NAD(P)H Dehydrogenase (Quinone);pharmacology;Plants,Medicinal;Rats;Research;humans.
- Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes.
- Authors: Gerhäuser C, You M, Liu J, Moriarty RM, Hawthorne M, Mehta RG, Moon RC, Pezzuto JM
- Issue date: 1997 Jan 15
- Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.
- Authors: Carcache-Blanco EJ, Kang YH, Park EJ, Su BN, Kardono LB, Riswan S, Fong HH, Pezzuto JM, Kinghorn AD
- Issue date: 2003 Sep
- Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes.
- Authors: Song LL, Kosmeder JW 2nd, Lee SK, Gerhäuser C, Lantvit D, Moon RC, Moriarty RM, Pezzuto JM
- Issue date: 1999 Feb 1
- Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells.
- Authors: Miranda CL, Aponso GL, Stevens JF, Deinzer ML, Buhler DR
- Issue date: 2000 Feb 28
- Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers.
- Authors: Dinkova-Kostova AT, Abeygunawardana C, Talalay P
- Issue date: 1998 Dec 17