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dc.contributor.authorTapio, Soile
dc.contributor.authorGrosche, Bernd
dc.date.accessioned2009-04-06T08:19:10Z
dc.date.available2009-04-06T08:19:10Z
dc.date.issued2006-06
dc.identifier.citationMutat. Res. 2006, 612 (3):215-246en
dc.identifier.issn0027-5107
dc.identifier.pmid16574468
dc.identifier.doi10.1016/j.mrrev.2006.02.001
dc.identifier.urihttp://hdl.handle.net/10146/64477
dc.descriptionKEYWORDS CLASSIFICATION: Arsenic;Biotransformation;cancer epidemiology;chemically induced;epidemiology;Environmental Exposure;Epidemiology,Molecular;Evaluation;genetics;Germany;Humans;Inhalation;metabolism;methods;Neoplasms;Occupational Exposure;Radiation Protection;toxicity.en
dc.description.abstractArsenic, one of the most significant hazards in the environment affecting millions of people around the world, is associated with several diseases including cancers of skin, lung, urinary bladder, kidney and liver. Groundwater contamination by arsenic is the main route of exposure. Inhalation of airborne arsenic or arsenic-contaminated dust is a common health problem in many ore mines. This review deals with the questions raised in the epidemiological studies such as the dose-response relationship, putative confounders and synergistic effects, and methods evaluating arsenic exposure. Furthermore, it describes the metabolic pathways of arsenic, and its biological modes of action. The role of arsenic in the development of cancer is elucidated in the context of combined epidemiological and biological studies. However, further analyses by means of molecular epidemiology are needed to improve the understanding of cancer aetiology induced by arsenic.
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T2G-4JKJTC3-1&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=82ea957e13464d68f0807adc28a7b371en
dc.subjectArsenicen
dc.subjectCanceren
dc.subjectDrinking wateren
dc.subjectMinesen
dc.subjectMolecular epidemiologyen
dc.subject.meshArsenic
dc.subject.meshBiotransformation
dc.subject.meshEnvironmental Exposure
dc.subject.meshEpidemiology, Molecular
dc.subject.meshHumans
dc.subject.meshNeoplasms
dc.subject.meshOccupational Exposure
dc.titleArsenic in the aetiology of cancer.en
dc.typeArticleen
dc.identifier.journalMutation researchen
html.description.abstractArsenic, one of the most significant hazards in the environment affecting millions of people around the world, is associated with several diseases including cancers of skin, lung, urinary bladder, kidney and liver. Groundwater contamination by arsenic is the main route of exposure. Inhalation of airborne arsenic or arsenic-contaminated dust is a common health problem in many ore mines. This review deals with the questions raised in the epidemiological studies such as the dose-response relationship, putative confounders and synergistic effects, and methods evaluating arsenic exposure. Furthermore, it describes the metabolic pathways of arsenic, and its biological modes of action. The role of arsenic in the development of cancer is elucidated in the context of combined epidemiological and biological studies. However, further analyses by means of molecular epidemiology are needed to improve the understanding of cancer aetiology induced by arsenic.


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