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dc.contributor.authorLesicka, Monika
dc.contributor.authorJabłońska, Ewa
dc.contributor.authorWieczorek, Edyta
dc.contributor.authorPepłońska, Beata
dc.contributor.authorGromadzińska, Jolanta
dc.contributor.authorSeroczyńska, Barbara
dc.contributor.authorKalinowski, Leszek
dc.contributor.authorSkokowski, Jarosław
dc.contributor.authorReszka, Edyta
dc.date.accessioned2020-01-15T09:14:56Z
dc.date.available2020-01-15T09:14:56Z
dc.date.issued2019-11-14
dc.identifier.citationInt J Mol Sci. 2019 Nov; 20(22): 5704.en_US
dc.identifier.issn1422-0067
dc.identifier.pmid31739444
dc.identifier.doi10.3390/ijms20225704
dc.identifier.urihttp://hdl.handle.net/10146/618338
dc.description.abstractBreast cancer (BC) is a major problem for civilization, manifested by continuously increasing morbidity and mortality among women worldwide. Core circadian genes may play an important role in cancer development and progression. To evaluate the effects of single nucleotide polymorphism (SNP) in circadian genes in BC risk, 16 functional SNPs were genotyped in 321 BC patients and 364 healthy women using the TaqMan fluorescence-labelled probes or High-Resolution Melt Curve technique in the Real-Time PCR system. The selected SNPs were analyzed for the risk of BC, progression, and the influence on gene expression in BC tissue pairs to demonstrate the functionality of genetic variants. The study showed a relationship between an increased BC risk under the dominant genetic model of CRY2 rs10838524, PER2 rs934945, and recessive genetic model of PER1 rs2735611. A protective effect of BMAL1 rs2279287 was observed among carriers with at least one variant allele. Moreover, we found an increased risk of estrogen-/progesterone-positive tumors under the dominant genetic model of PER2 rs934945 and estrogen negative tumors under the variant genotype of CRY2 rs10838524, PER1 rs2735611. We demonstrated significantly altered gene expression of BMAL1, CRY2, PER1, PER2, PER3 according to particular genotypes in the BC tissue pairs. Our findings support the hypothesized role of circadian genes in breast carcinogenesis and indicate probable biomarkers for breast cancer susceptibility.en_US
dc.language.isoenen_US
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888181/en_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectbreast canceren_US
dc.subjectcircadian genesen_US
dc.subjectcircadian rhythmen_US
dc.subjectgene expressionen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.titleCircadian Gene Polymorphisms Associated with Breast Cancer Susceptibility.en_US
dc.typeArticleen_US
dc.contributor.departmentNofer Institute of Occupational Medicineen_US
dc.identifier.journalInternational Journal of Molecular Sciencesen_US
dc.source.journaltitleInternational journal of molecular sciences
refterms.dateFOA2020-01-15T09:14:57Z


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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States