Determinants of phthalate exposure and risk assessment in children from Poland.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Koch, Holger M
AffiliationNofer Institute of Occupational Medicine
MetadataShow full item record
AbstractPhthalates are a group of widely used chemicals and humans are exposed to them in their daily life. Some phthalates may affect the hormonal balance in both children and adults. The aim of this study was to assess the phthalate exposure and its determinants among children at age of 7 years from the Polish Mother and Child Cohort Study (REPRO_PL). 250 urine samples collected in 2014-2015 were analysed for 21 metabolites of 11 parent phthalates using on-line high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS). This represents the most extensive set of phthalate metabolites ever determined for Poland. Ten metabolites were quantifiable in 100% of the samples, another eight in >90%. The highest median concentrations were found for the primary monoester metabolites of di-iso-butyl (MiBP, 72.4 μg/l), di-n-butyl (MnBP, 56.3 μg/l) and diethyl (MEP, 42.0 μg/l) phthalate, followed by the sum of di-2-ethylhexyl (ΣDEHP, 89.3 μg/l) and di-iso-nonyl (ΣDiNP, 21.9 μg/l) phthalate metabolites. Metabolite concentrations were higher in children at 7 years than in the same children at age 2 or in their mothers during pregnancy. Generally, phthalate exposures in this study were much higher than exposures reported in other European populations. Multivariate regression models showed that body mass index, place of residence, breastfeeding duration, socio-economic status and parental education were associated with the metabolite levels in the 7-year old children. Daily intake and hazard index calculations revealed that a small percentage of children (around 3-10%) exceeded the tolerable daily intakes established by international institutions such as EFSA and U.S. EPA indicating that these children might be at risk of anti-androgenic effects from the individual and cumulative exposure to phthalates. Thus, further monitoring of this population, by educational programs and follow-up interventions, is required.
CitationEnviron. Int. 2019; 127: 742-753
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States
- Exposure to Mixed Phthalates in Czech Preschool and School Children.
- Authors: Puklová V, Janoš T, Sochorová L, Vavrouš A, Vrbík K, Fialová A, Hanzlíková L, Černá M
- Issue date: 2019 Nov
- Phthalate metabolites in obese individuals undergoing weight loss: Urinary levels and estimation of the phthalates daily intake.
- Authors: Dirtu AC, Geens T, Dirinck E, Malarvannan G, Neels H, Van Gaal L, Jorens PG, Covaci A
- Issue date: 2013 Sep
- Effect of environmental phthalate exposure on pregnancy duration and birth outcomes.
- Authors: Polańska K, Ligocka D, Sobala W, Hanke W
- Issue date: 2016
- Biomonitoring of phthalate metabolites in the Canadian population through the Canadian Health Measures Survey (2007-2009).
- Authors: Saravanabhavan G, Guay M, Langlois É, Giroux S, Murray J, Haines D
- Issue date: 2013 Nov
- Human biomonitoring of phthalate exposure in Austrian children and adults and cumulative risk assessment.
- Authors: Hartmann C, Uhl M, Weiss S, Koch HM, Scharf S, König J
- Issue date: 2015 Jul