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dc.contributor.authorLi, Yafang
dc.contributor.authorXiao, Xiangjun
dc.contributor.authorBossé, Yohan
dc.contributor.authorGorlova, Olga
dc.contributor.authorGorlov, Ivan
dc.contributor.authorHan, Younghun
dc.contributor.authorByun, Jinyoung
dc.contributor.authorLeighl, Natasha
dc.contributor.authorJohansen, Jakob S
dc.contributor.authorBarnett, Matt
dc.contributor.authorChen, Chu
dc.contributor.authorGoodman, Gary
dc.contributor.authorCox, Angela
dc.contributor.authorTaylor, Fiona
dc.contributor.authorWoll, Penella
dc.contributor.authorWichmann, H Erich
dc.contributor.authorManz, Judith
dc.contributor.authorMuley, Thomas
dc.contributor.authorRisch, Angela
dc.contributor.authorRosenberger, Albert
dc.contributor.authorHan, Jiali
dc.contributor.authorSiminovitch, Katherine
dc.contributor.authorArnold, Susanne M
dc.contributor.authorHaura, Eric B
dc.contributor.authorBolca, Ciprian
dc.contributor.authorHolcatova, Ivana
dc.contributor.authorJanout, Vladimir
dc.contributor.authorKontic, Milica
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorMukeria, Anush
dc.contributor.authorOgnjanovic, Simona
dc.contributor.authorOrlowski, Tadeusz M
dc.contributor.authorScelo, Ghislaine
dc.contributor.authorSwiatkowska, Beata
dc.contributor.authorZaridze, David
dc.contributor.authorBakke, Per
dc.contributor.authorSkaug, Vidar
dc.contributor.authorZienolddiny, Shanbeh
dc.contributor.authorDuell, Eric J
dc.contributor.authorButler, Lesley M
dc.contributor.authorHoulston, Richard
dc.contributor.authorArtigas, María Soler
dc.contributor.authorGrankvist, Kjell
dc.contributor.authorJohansson, Mikael
dc.contributor.authorShepherd, Frances A
dc.contributor.authorMarcus, Michael W
dc.contributor.authorBrunnström, Hans
dc.contributor.authorManjer, Jonas
dc.contributor.authorMelander, Olle
dc.contributor.authorMuller, David C
dc.contributor.authorOvervad, Kim
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorTumino, Rosario
dc.contributor.authorLiu, Geoffrey
dc.contributor.authorBojesen, Stig E
dc.contributor.authorWu, Xifeng
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorAlbanes, Demetrios
dc.contributor.authorBickeböller, Heike
dc.contributor.authorAldrich, Melinda C
dc.contributor.authorBush, William S
dc.contributor.authorTardon, Adonina
dc.contributor.authorRennert, Gad
dc.contributor.authorTeare, M Dawn
dc.contributor.authorField, John K
dc.contributor.authorKiemeney, Lambertus A
dc.contributor.authorLazarus, Philip
dc.contributor.authorHaugen, Aage
dc.contributor.authorLam, Stephen
dc.contributor.authorSchabath, Matthew B
dc.contributor.authorAndrew, Angeline S
dc.contributor.authorBertazzi, Pier Alberto
dc.contributor.authorPesatori, Angela C
dc.contributor.authorChristiani, David C
dc.contributor.authorCaporaso, Neil
dc.contributor.authorJohansson, Mattias
dc.contributor.authorMcKay, James D
dc.contributor.authorBrennan, Paul
dc.contributor.authorHung, Rayjean J
dc.contributor.authorAmos, Christopher I
dc.date.accessioned2019-05-08T10:50:14Z
dc.date.available2019-05-08T10:50:14Z
dc.date.issued2019-03-05
dc.identifier.citationOncotarget. 2019; 10(19):1760-1774.en_US
dc.identifier.issn1949-2553
dc.identifier.pmid30956756
dc.identifier.doi10.18632/oncotarget.26678
dc.identifier.urihttp://hdl.handle.net/10146/618299
dc.description.abstractThe development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer development, we conducted pairwise genetic interaction analyses among 35,031 SNPs from 2027 oncogenesis-related genes. The genotypes from three independent genome-wide association studies including a total of 24,037 lung cancer patients and 20,401 healthy controls with Caucasian ancestry were analyzed in the study. Using a two-stage study design including discovery and replication studies, and stringent Bonferroni correction for multiple statistical analysis, we identified significant genetic interactions between SNPs inen_US
dc.language.isoenen_US
dc.relation.urlhttp://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=26678&path[]=82935en_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectepistasisen_US
dc.subjectfunctional annotationen_US
dc.subjectlung canceren_US
dc.subjectoncogenesisen_US
dc.titleGenetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.en_US
dc.typeArticleen_US
dc.contributor.departmentNofer Institute of Occupational Medicineen_US
dc.identifier.journalONCOTARGETen_US
dc.source.journaltitleOncotarget
refterms.dateFOA2019-05-08T10:50:15Z


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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States