The distribution and excretion of 1-Methylnaphthalene in rats exposed to 1-Methylnaphthalene by inhalation.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AffiliationNofer Institute of Occupational Medicine
MetadataShow full item record
Abstract1-Methylnaphthalene (1-MN) is a constituent of polycyclic aromatic hydrocarbons, the chemicals that have become ubiquitous in the environment as result of natural and industrial process. This paper reports a study on the distribution and excretion of 1-MN in rats after single and repeated inhalation exposure to 1-MN vapor. Male Wistar rats were exposed to 1-MN vapor at nominal concentrations of 50 mg/m3 or 200 mg/m3 in the dynamic inhalation chambers (TSE Systems Head Nose Only Exposure) for 6 h (single exposure) or 5 days (6 h/day, repeated exposure). Blood, urine and tissue samples were collected during and after the exposure. Blood, urine and tissue concentrations of 1-MN were estimated by gas chromatography using the headspace technique. The elimination of 1-MN from blood followed an open 2-compartment model. The concentration in rat tissues was dependent on the magnitude and time of exposure. After repeated exposure, the concentration 1-MN in tissue decreased in comparison to single exposure. The elimination of 1-MN with urine after single and repeated exposure to 1-MN occurred mainly in the samples collected during the first day of collection. 1-Methylnaphthalene was rapidly eliminated from the blood and tissues of animals exposed by inhalation to 1-MN. In repeated exposure, there was probably a significant increase of 1-MN metabolism in rats exposed to low and high 1-MN doses. Under conditions of repeated 1-MN exposure, no significant systemic 1-MN accumulation could be observed. Int J Occup Med Environ Health 2018;31(6):763-770.
CitationInt J Occup Med Environ Health 2018;31(6):763–770
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Attribution-NonCommercial 3.0 United States
- The toxicokinetics of 2-methylnaphtalene in rats.
- Authors: Swiercz R, Wąsowicz W, Majcherek W
- Issue date: 2010
- MTBE inhaled alone and in combination with gasoline vapor: uptake, distribution, metabolism, and excretion in rats.
- Authors: Benson JM, Barr EB, Krone JR
- Issue date: 2001 May
- 4-Week inhalation toxicity of 2-methylnaphthalene in experimental animals.
- Authors: Swiercz R, Wąsowicz W, Stetkiewicz J, Gromadzińska J, Majcherek W
- Issue date: 2011 Dec
- Hemimellitene (1,2,3-trimethylbenzene) in the liver, lung, kidney, and blood, and dimethylbenzoic acid isomers in the liver, lung, kidney and urine of rats after single and repeated inhalation exposure to hemimellitene.
- Authors: Świercz R, Majcherek W, Wąsowicz W
- Issue date: 2016
- Pseudocumene in brain, liver, lung and blood of rats after single and repeated inhalation exposure.
- Authors: Swiercz R, Wiaderna D, Wasowicz W, Rydzyński K
- Issue date: 2003