Sex-Dependent Impact of Low-Level Lead Exposure during Prenatal Period on Child Psychomotor Functions.
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AffiliationNofer Institute of Occupational Medicine
MetadataShow full item record
AbstractThe impact of exposure to lead on child neurodevelopment has been well established. However, sex differences in vulnerability are still not fully explained. We aimed at evaluating the effect of a low-level lead exposure, as measured between 20 to 24 weeks of pregnancy and in cord blood, on developmental scores up to 24 months of age in 402 children from the Polish Mother and Child Cohort (REPRO_PL). Additionally, sex-dependent susceptibility to lead at this very early stage of psychomotor development was assessed. The blood lead levels were analyzed using inductively coupled plasma mass spectrometry (ICP-MS). In order to estimate the children's neurodevelopment, the Bayley Scales of Infant and Toddler Development was applied. The geometric mean (GM) for blood lead level during 20⁻24 weeks of pregnancy was 0.99 ± 0.15 µg/dL and, in the cord blood, it was 0.96 ± 0.16 µg/dL. There was no statistically significant impact of lead exposure during prenatal period on the girls' psychomotor abilities. Among the boys, we observed lower scores for cognitive functions, along with increasing cord blood lead levels (β = -2.07;
CitationInt J Environ Res Public Health. 2018; 15(10): 2263.
SponsorsThis work has been funded by the National Science Centre under the call JPI HDHL Nutrition and Cognitive Function (2015/17/Z/NZ7/04273) and the National Science Centre, Poland, under the grant No. DEC-2014/15/B/NZ7/00998 and partly by the European Community’s Seventh Framework Program (FP7/2007–2013) under HEALS (grant agreement No. 603946) and the Ministry of Science and Higher Education under grant agreement No. 3068/7.PR/2014/2.
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