Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood-Lack of Association with Tobacco Smoke Exposure.
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Authors
Gromadzinska, JolantaPolanska, Kinga
Kozlowska, Lucyna
Mikolajewska, Karolina
Stelmach, Iwona
Jerzyńska, Joanna
Stelmach, Włodzimierz
Grzesiak, Mariusz
Hanke, Wojciech
Wasowicz, Wojciech
Affiliation
Nofer Institute of Occupational MedicineIssue Date
2018
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Show full item recordAbstract
Epidemiological studies have suggested an association between maternal antioxidant levels during pregnancy and development of allergic diseases in their offspring. The aim of the study was to determine plasma vitamins A and E concentration in the 1st trimester of pregnancy, at delivery and in cord blood and to search for a relationship with allergy in up to 2-year-old children who were prenatally exposed or not exposed to tobacco smoke. The study participants included 252 mother-child pairs from Polish Mother and Child Cohort. Vitamin concentrations were measured using the HPLC-UV method, smoking status—as saliva cotinine level using the HPLC-MS/MS technique. Children’s health status was assessed using a questionnaire and pediatricians/allergists examination. Cord plasma vitamin concentrations were significantly lower than their levels in maternal plasma in the 1sttrimester and at delivery (p < 0.001). Significantly higher concentrations of vitamin E have been shown to occur during the 1st trimester of pregnancy in plasma of the women who have actively/passively smoked cigarettes compared to the non-smokers (p < 0.02). Multivariate analysis with inclusion of a variety of confounding factors have not indicated any statistically significant associations between β-carotene, vitamins A and E and the risk of food allergy, atopic dermatitis and wheezing in their children up to 2 years of age. The interaction between smoking during pregnancy and vitamins levels on the risk of allergy was not statistically significant (p < 0.4). The relationship between plasma concentration of vitamins A and E, and the risk of allergy in their young children has not been demonstrated.Citation
Int J Environ Res Public Health 2018, 15 (6) art: E1245.PubMed ID
29895780Additional Links
https://www.mdpi.com/1660-4601/15/6/1245Type
ArticleLanguage
enISSN
1660-4601ae974a485f413a2113503eed53cd6c53
10.3390/ijerph15061245
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Except where otherwise noted, this item's license is described as Archived with thanks to International journal of environmental research and public health