Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Radwan, MichałWielgomas, Bartosz
Dziewirska, Emila
Radwan, Paweł
Kałużny, Paweł
Klimowska, Anna
Hanke, Wojciech
Jurewicz, Joanna
Affiliation
Nofer Institute of Occupational MedicineIssue Date
2018-11
Metadata
Show full item recordAbstract
Bisphenol A (BPA) is a high-production volume industrial chemical found in many consumer products. BPA is a suspected potent endocrine disruptor, with endocrine-disrupting properties demonstrated in animal studies. Few human studies have examined bisphenol A exposure in relation to male fertility and, results are divergent. The aim of the study is to examine the associations between urinary BPA concentration and male fertility. Bisphenol A urinary concentrations were measured using gas chromatography coupled with tandem mass spectrometry in 315 men under 45 years of age with normal sperm concentration (⩾15 mln/ml) recruited from a male reproductive health clinic. Participants were interviewed and provided a semen sample. BPA was detected in 98.10% of urine samples, with a median concentration of 1.87 µg/l (1.63 µg/ g creatinine). A multiple linear regression analysis identified a positive association between the urinary concentrations of bisphenol A 25th-50th percentile and total sperm sex chromosome disomy ( p = .004). Also when modeled as continuous variable urinary BPA concentration increased total sperm sex chromosome disomy ( p = .01). Urinary concentration of BPA also increase the percentage of immature sperm (HDS) ( p = .018) and decrease motility ( p = .03). The study provides evidence that exposure to BPA is associated with poorer semen quality. Future studies are needed to confirm these findings.Citation
Am J Mens Health 2018, 12 (6):2144-2151Journal
American Journal of Men's HealthPubMed ID
30261816Additional Links
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199454/Type
ArticleLanguage
enISSN
1557-9891ae974a485f413a2113503eed53cd6c53
10.1177/1557988318799163
Scopus Count
Collections
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Archived with thanks to American journal of men's health
Related articles
- Urinary bisphenol A concentrations are associated with reproductive parameters in young men.
- Authors: Adoamnei E, Mendiola J, Vela-Soria F, Fernández MF, Olea N, Jørgensen N, Swan SH, Torres-Cantero AM
- Issue date: 2018 Feb
- Urinary bisphenol A and semen quality, the LIFE Study.
- Authors: Goldstone AE, Chen Z, Perry MJ, Kannan K, Louis GM
- Issue date: 2015 Jan
- Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality.
- Authors: Lassen TH, Frederiksen H, Jensen TK, Petersen JH, Joensen UN, Main KM, Skakkebaek NE, Juul A, Jørgensen N, Andersson AM
- Issue date: 2014 May
- Environmental levels of triclosan and male fertility.
- Authors: Jurewicz J, Radwan M, Wielgomas B, Kałużny P, Klimowska A, Radwan P, Hanke W
- Issue date: 2018 Feb
- Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic.
- Authors: Meeker JD, Ehrlich S, Toth TL, Wright DL, Calafat AM, Trisini AT, Ye X, Hauser R
- Issue date: 2010 Dec