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dc.contributor.authorBukowska-Damska, Agnieszka
dc.contributor.authorReszka, Edyta
dc.contributor.authorKaluzny, Pawel
dc.contributor.authorWieczorek, Edyta
dc.contributor.authorPrzybek, Monika
dc.contributor.authorZienolddiny, Shanbeh
dc.contributor.authorPeplonska, Beata
dc.date.accessioned2018-12-05T09:15:50Z
dc.date.available2018-12-05T09:15:50Z
dc.date.issued2018
dc.identifier.citationChronobiol. Int. 2018, 35 (1):122-131en
dc.identifier.issn1525-6073
dc.identifier.pmid29144154
dc.identifier.doi10.1080/07420528.2017.1376219
dc.identifier.urihttp://hdl.handle.net/10146/618244
dc.description.abstractChronic sleep restriction may affect metabolism, hormone secretion patterns and inflammatory responses. Limited reports suggest also epigenetic effects, such as changes in DNA methylation profiles. The study aims to assess the potential association between poor sleep quality or sleep duration and the levels of 5-methylcytosine in the promoter regions of selected tumor suppressor genes. A cross-sectional study was conducted on 710 nurses and midwives aged 40-60 years. Data from interviews regarding sleep habits and potential confounders were used. The methylation status of tumor suppressor genes was determined via qMSP reactions using DNA samples derived from leucocytes. No significant findings were observed in the total study population or in the two subgroups of women stratified by the current system of work. A borderline significance association was observed between a shorter duration of sleep and an increased methylation level in CDKN2A among day working nurses and midwives. Further studies are warranted to explore this under-investigated topic.
dc.description.sponsorshipThis project was supported by the Norway Grants, under the Polish-Norwegian Research Programme (Grant no. PNRF – 243 – AI – 1/07 and Pol-Nor/196940/22/2013-clockshift).en
dc.language.isoenen
dc.relation.urlhttps://www.tandfonline.com/doi/abs/10.1080/07420528.2017.1376219?journalCode=icbi20en
dc.rightsArchived with thanks to Chronobiology internationalen
dc.subjectDNA methylationen
dc.subjectnurses and midwivesen
dc.subjectshiftworken
dc.subjecttumor suppressor genesen
dc.titleSleep quality and methylation status of selected tumor suppressor genes among nurses and midwives.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicineen
dc.identifier.journalChronobiology Internationalen
html.description.abstractChronic sleep restriction may affect metabolism, hormone secretion patterns and inflammatory responses. Limited reports suggest also epigenetic effects, such as changes in DNA methylation profiles. The study aims to assess the potential association between poor sleep quality or sleep duration and the levels of 5-methylcytosine in the promoter regions of selected tumor suppressor genes. A cross-sectional study was conducted on 710 nurses and midwives aged 40-60 years. Data from interviews regarding sleep habits and potential confounders were used. The methylation status of tumor suppressor genes was determined via qMSP reactions using DNA samples derived from leucocytes. No significant findings were observed in the total study population or in the two subgroups of women stratified by the current system of work. A borderline significance association was observed between a shorter duration of sleep and an increased methylation level in CDKN2A among day working nurses and midwives. Further studies are warranted to explore this under-investigated topic.


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