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dc.contributor.authorWieczorek, Edyta
dc.contributor.authorReszka, Edyta
dc.date.accessioned2018-12-04T09:54:40Z
dc.date.available2018-12-04T09:54:40Z
dc.date.issued2018-02
dc.identifier.citationClin. Chim. Acta 2018, 477:141-153en
dc.identifier.issn1873-3492
dc.identifier.pmid29224950
dc.identifier.doi10.1016/j.cca.2017.12.009
dc.identifier.urihttp://hdl.handle.net/10146/618235
dc.description.abstractEarly detection of bladder cancer (BC) is essential for improvement of the patient's prognosis and general survival rates. Current diagnostic methods are still limited, so new specific and cost-effective biomarkers are emerging as the noninvasive tools in treatment decisions in recurrent BC. Gene expression and epigenetic profile can be analysed using quantitative real-time-PCR (qRT-PCR) method in urine, blood and tissue. This review provides an update of recent findings on BC molecular profile as novel markers in diagnosis and prognosis of bladder tumors. We describe mRNA-, microRNA- and lncRNA-based biomarkers involved in the BC detection, diagnosis, prediction of recurrence and monitoring after treatment.
dc.description.sponsorshipThis research was supported by Internal Grant IMP (14.2 and 1.39), and by the National Science Centre, Poland (2012/05/B/NZ5/01406 and 2016/23/N/NZ5/01408).en
dc.language.isoenen
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0009898117304941?via%3Dihuben
dc.rightsArchived with thanks to Clinica chimica acta; international journal of clinical chemistryen
dc.subjectbladder canceren
dc.subjectMolecular markersen
dc.subjectlncRNAen
dc.subjectmRNAen
dc.subjectmicroRNAen
dc.subjectqRT-PCRen
dc.subject.meshBiomarkers, Tumor
dc.subject.meshHumans
dc.subject.meshMicroRNAs
dc.subject.meshRNA, Long Noncoding
dc.subject.meshRNA, Messenger
dc.subject.meshReal-Time Polymerase Chain Reaction
dc.subject.meshUrinary Bladder Neoplasms
dc.titlemRNA, microRNA and lncRNA as novel bladder tumor markers.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicineen
dc.identifier.journalClinica Chimica Actaen
html.description.abstractEarly detection of bladder cancer (BC) is essential for improvement of the patient's prognosis and general survival rates. Current diagnostic methods are still limited, so new specific and cost-effective biomarkers are emerging as the noninvasive tools in treatment decisions in recurrent BC. Gene expression and epigenetic profile can be analysed using quantitative real-time-PCR (qRT-PCR) method in urine, blood and tissue. This review provides an update of recent findings on BC molecular profile as novel markers in diagnosis and prognosis of bladder tumors. We describe mRNA-, microRNA- and lncRNA-based biomarkers involved in the BC detection, diagnosis, prediction of recurrence and monitoring after treatment.


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