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AbstractTriclosan is a synthetic chemical with broad antimicrobial activity that has been used extensively in consumer products, including personal care products, textiles, and plastic kitchenware, although the exposure which is widespread evidence from human studies is scarce. Our study aims to investigate the relationship between triclosan exposure and male fertility. Triclosan (TCS) urinary concentrations were measured using gas chromatography coupled with tandem mass spectrometry in 315 men recruited from a male reproductive health clinic with normal sperm concentration (≥ 15 mln/ml) (WHO 2010) under 45 years of age. Participants were interviewed and provided a semen sample. TCS was detected in 84.13% of urine samples, with a median concentration of 2.83 μg/l (2.57 μg/g creatinine). A multiple linear regression analysis showed a positive association between the urinary concentrations of triclosan 50th-75th percentile and ≥ 50 percentile and percentage of sperm with abnormal morphology (p = 0.016 and p = 0.002, respectively). The study provides evidence that exposure to triclosan is associated with poorer semen quality. Future studies are needed to confirm these findings.
CitationEnviron Sci Pollut Res Int (2017)
SponsorsThis study was performed under the project "The association between environmental exposure to widespread man made endocrine-disrupting chemicals and level of hormones associated with the activity of hypothalamic pituitary testicular axis among young men" supported by the National Science Centre in Poland from grant no. UMO-2014/13/B/NZ7/02223 and the project financed with a grant for statutory activity IMP 10.31/2017
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Except where otherwise noted, this item's license is described as Archived with thanks to Environmental science and pollution research international
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