Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
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Olshan, Andrew F
Ness, Andrew R
Macfarlane, Gary J
Menezes, Ana M
Curado, Maria Paula
Conway, David I
Healy, Claire M
Grandis, Jennifer R
Weissler, Mark C
Tajara, Eloiza H
Nunes, Fabio D
de Carvalho, Marcos B
Hung, Rayjean J
Peters, Wilbert H M
Bueno-de-Mesquita, H Bas
Amos, Christopher I
McKay, James D
MetadataShow full item record
AbstractWe conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers.
CitationNat. Genet. 2016, 48 (12):1544-1550
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Except where otherwise noted, this item's license is described as Archived with thanks to Nature genetics
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