A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Jaddoe, Vincent W V
Den Dekker, Herman T
Godfrey, Keith M
Jacobsen, Geir W
MetadataShow full item record
AbstractMaternal smoking during pregnancy is linked to reduced birth weight but the gestation at onset of this relationship is not certain. We present a systematic review of the literature describing associations between maternal smoking during pregnancy and ultrasound measurements of fetal size, together with an accompanying meta-analysis.
Studies were selected from electronic databases (OVID, EMBASE and Google Scholar) that examined associations between maternal smoking or smoke exposure and antenatal fetal ultrasound measurements. Outcome measures were first, second or third trimester fetal measurements.
There were 284 abstracts identified, 16 papers were included in the review and the meta-analysis included data from eight populations. Maternal smoking was associated with reduced second trimester head size (mean reduction 0.09 standard deviation (SD) [95% CI 0.01, 0.16]) and femur length (0.06 [0.01, 0.10]) and reduced third trimester head size (0.18 SD [0.13, 0.23]), femur length (0.27 SD [0.21, 0.32]) and estimated fetal weight (0.18 SD [0.11, 0.24]). Higher maternal cigarette consumption was associated with a lower z score for head size in the second (mean difference 0.09 SD [0, 0.19]) and third (0.15 SD [0.03, 0.26]) trimesters compared to lower consumption. Fetal measurements were not reduced for those whose mothers quit before or after becoming pregnant compared to mothers who had never smoked.
Maternal smoking during pregnancy is associated with reduced fetal measurements after the first trimester, particularly reduced head size and femur length. These effects may be attenuated if mothers quit or reduce cigarette consumption during pregnancy.
CitationPLoS ONE 2017, 12 (2):e0170946
SponsorsThe study was supported by the European Cooperation in Science and Technology, who provided funds for publication. KMG is supported by the National Institute for Health Research through the NIHR Southampton Biomedical Research Centre and by the European Union's Seventh Framework Programme (FP7/2007-2013), projects Early Nutrition and ODIN under grant agreement numbers 289346 and 613977.
The following license files are associated with this item:
- First trimester maternal tobacco smoking habits and fetal growth.
- Authors: Prabhu N, Smith N, Campbell D, Craig LC, Seaton A, Helms PJ, Devereux G, Turner SW
- Issue date: 2010 Mar
- A systematic review of associations between maternal exposures during pregnancy other than smoking and antenatal fetal measurements.
- Authors: Huang I, Mak D, Cheung P, Abraham M, Clemens T, Turner S
- Issue date: 2019 Jun
- The relationship between maternal opiate use, amphetamine use and smoking on fetal growth.
- Authors: Delsing C, Van Den Wittenboer E, Liu AJ, Peek MJ, Quinton A, Mongelli M, Poulton A, Nanan R
- Issue date: 2011 Oct
- Associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth: Findings from Mendelian randomization and parental negative control studies.
- Authors: Brand JS, Gaillard R, West J, McEachan RRC, Wright J, Voerman E, Felix JF, Tilling K, Lawlor DA
- Issue date: 2019 Nov
- Tracking of fetal growth characteristics during different trimesters and the risks of adverse birth outcomes.
- Authors: Gaillard R, Steegers EA, de Jongste JC, Hofman A, Jaddoe VW
- Issue date: 2014 Aug