Balkan endemic nephropathy: role of ochratoxins A through biomarkers.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Chernozemsky, Ivan N.
MetadataShow full item record
AbstractSeveral studies implicated mycotoxins, in endemic kidney disease geographically limited to Balkan region (Balkan endemic nephropathy (BEN)). In Bulgaria, much higher prevalence of ochratoxin A (OTA), exceeding 2 microg/L, was observed in the blood of affected population. OTA is found more often in the urine of people living in BEN-endemic villages. To confirm and quantify exposure to OTA in Vratza district, we followed up OTA intake for 1 month, OTA in blood and urine from healthy (20-30 years old) volunteers, from two villages with high risk for BEN disease. Food samples were collected daily, blood and urine at the beginning of each week. Relations between increasing OTA intake, blood concentration and elimination of OTA in urine have been studied in rats. Average weekly intake of OTA varies from 1.9 to 206 ng/kg body weight, twice tolerable weekly intake recommended by JECFA. OTA blood concentrations are in the same range as previously reported in this region with concentrations reaching 10 microg/L. Weekly OTA food intake is not directly correlated with blood and urine concentrations. Biomarkers of biological effects such as DNA adducts were detected in patients affected by urinary tract tumours (UTT) and in rat study. All these plead for the implication of OTA, in BEN and UTT.
CitationMol. Nutr. Food Res. 2006, 50 (6):519-529
DescriptionBiomarker: DNA adductsExposure/effect represented: ochratoxin A (OTA) / DNA damageStudy type: humans, Dark Agouti ratsStudy design: cross-sectional studyStudy size: 16 healthy volunteersAnalytical technique: OTA food intake, OTA blood concentration and urinary OTA excretion; DNA adducts in kidney of male and female rats using post labellingTissue/biological material/sample size: human blood and urine; Dark Agouti rat blood, urine and kidneyImpact on outcome (including dose-response): Average weekly intake of OTA varies from 1.9 to 206 ng/kg body weight, twice tolerable weekly intake recommended by JECFA. OTA blood concentrations are in the same range as previously reported in this region with concentrations reaching 10 microg/L. Weekly OTA food intake is not directly correlated with blood and urine concentrations. Biomarkers of biological effects such as DNA adducts were detected in patients affected by urinary tract tumours (UTT) and in rat study. KEYWORDS - CLASSIFICATION: administration & dosage;Adult;analysis;Animals;Balkan Nephropathy;Biological Markers;biomarkers of exposure & effect: field studies;blood;chemically induced;chemistry;Diet;DNA Adducts;Female;field studies;Food;Food Contamination;France;genetics;Humans;Kidney;Male;Ochratoxins;Pedigree;Rats;Research;Sex Characteristics;Triticum;urine;Urologic Neoplasms;
- Molecular and epidemiological approaches to the etiology of urinary tract tumors in an area with Balkan endemic nephropathy.
- Authors: Nikolov IG, Petkova-Bocharova D, Castegnaro M, Pfohl-Leskowicz A, Gill C, Day N, Chernozemsky IN
- Issue date: 1996
- Analysis of ochratoxin A in foods consumed by inhabitants from an area with balkan endemic nephropathy: a 1 month follow-up study.
- Authors: Vrabcheva T, Petkova-Bocharova T, Grosso F, Nikolov I, Chernozemsky IN, Castegnaro M, Dragacci S
- Issue date: 2004 Apr 21
- Ochratoxin A concentrations in food and feed from a region with Balkan Endemic Nephropathy.
- Authors: Abouzied MM, Horvath AD, Podlesny PM, Regina NP, Metodiev VD, Kamenova-Tozeva RM, Niagolova ND, Stein AD, Petropoulos EA, Ganev VS
- Issue date: 2002 Aug
- Ochratoxin A as a potential etiologic factor in endemic nephropathy: lessons from toxicity studies in rats.
- Authors: Mally A, Hard GC, Dekant W
- Issue date: 2007 Nov
- Ochratoxin A in human blood in relation to Balkan endemic nephropathy and urinary tract tumours in Bulgaria.
- Authors: Petkova-Bocharova T, Castegnaro M
- Issue date: 1991