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AbstractThe people studied were male volunteers without occupational and dietary exposure to PAH: 27 smokers (10 cigarettes or more) and 27 non-smokers matched for age and socio-professional category. For each person, all the 24h voided urine samples were reassembled in a single sample. 1-Hydroxypyrene (1-OHPy) and 3-hydroxybenzo[a]pyrene (3-OHBaP) were then determined by automated column-switching high-performance liquid chromatography. Urinary 1-OHPy ranged from 0.041 to 0.530 micromol/molCreatinine (arithmetic mean 0.144, median 0.115) for smokers and from 0.01 to 0.148 mmol/molCreatinine (arithmetic mean 0.044, median 0.032) for non-smokers. These values are close to those of some other studies. Urinary 3-OHBaP ranged from <0.01 to 0.084 nmol/molCreatinine (arithmetic mean 0.030, median 0.023) for smokers and from <0.01 to 0.045 nmol/molCreatinine (arithmetic mean 0.014, median 0.011) for non-smokers. Considering more particularly the urinary 3-OHBaP values, the influence of smoking could be important among workers exposed to low levels of BaP (<100 ng/m(3)) and the concentrations for smokers were equivalent to most of the preshift values of exposed workers. The dietary BaP intake was slightly lower than the BaP intake for an average smoker. From the present study, temporary basic reference levels may be proposed for urinary 3-OHBaP.
CitationToxicol. Lett. 2006, 162 (2-3):181-185
DescriptionLifestyle modulation of cancer & cancer biomarkersLifestyle element evaluated: smoking Outcome studied (cancer or cancer biomarker): Urinary 3-hydroxybenzo[a]pyrene (3-OHBaP)Method of biomarker analysis: HPLCStudy type (in vitro, animals, humans): humansStudy design (if human): cross-sectionalStudy size (if human): 27 smokers, 27 non-smokersDescription of cohort(s) studied (if human): The subjects studied were healthy male volunteers between18 and 65 years of age, non-occupationally exposed to PAH, matched for age (±5 years) and socioprofessional categoryDose-response relationships observed: Urinary 3-OHBaP ranged from <0.01 to 0.084 nmol/ molCreatinine (arithmetic mean 0.030, median 0.023) for smokers and from <0.01 to 0.045 nmol/ molCreatinine (arithmetic mean 0.014, median 0.011) for non-smokers The 1-OHPy excreted amount/24 h ranged from 129 to 1157 ng (arithmetic mean 494 ng) for smokers and from 24 to 523 ng for non-smokers (mean 146 ng).The 3-OHBaP excreted amount/24 h ranged from <40 to 367 pg for smokers (mean 131 pg) and from <44 to 224 pg for non-smokers (mean 59 pg). KEYWORDS CLASSIFICATION: Adult;biomarkers of exposure & effect: field studies;Benzopyrenes;Biological Markers;Environmental Monitoring;France;Humans;metabolism;Male;Middle Aged;Occupational Exposure;Pyrenes;Smoking;urine.
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