Anticancer effect of Kalpaamruthaa on mammary carcinoma in rats with reference to glycoprotein components, lysosomal and marker enzymes.
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AffiliationDepartment of Medical Biochemistry, Dr. A. L. Mudaliar Post-Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India.
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AbstractA promising approach to reduce the occurrence of cancer is its treatment, specifically by chemical intervention through minor dietary constituents. Epidemiological studies suggest that specific pharmacologically active agents present in the diet might reduce cancer. A remarkable surge of interest in chemoprevention research has, thus, lead to the identification of many phytochemicals of dietary origin as effective potential chemotherapeutic agents. In the present investigation, attempt has been made to study the potency of Kalpaamruthaa (KA), a herbal preparation, against cancer. The changes in level of glycoprotein components, marker enzymes and lysosomal enzymes were carried out in 7,12-dimethylbenz(a)anthracene (DMBA) induced Sprague-Dawley rats. The changes in the body weights and volume were also determined. KA was administered at the dosage level of 100, 200, 300, 400 and 500 mg/kg body weight (BW) in olive oil orally for 14 d, after the induction period is completed (90 d). On administration of KA, the levels of the above enzymes and the changes in the body weights and volume were significantly normalized in a dose dependent manner. The present study shows that KA is effective at the dosage level of 300 mg/kg body weight in mammary carcinoma bearing rats.
CitationBiol. Pharm. Bull. 2006, 29 (3):565-569
DescriptionDietary modulation of carcinogenesis-related pathwaysDietary item or component studied:kaplaamruthaa (KA)Pathways studied:enzymatic activitiesStudy type (in vitro, animals, humans): sprague-Dawley ratsTissue/biological material/sample size:liver, kidney, bloodMode of exposure (if in vivo) (acute, chronic, root of exposure): through diet (7 groups)Impact on pathway (including dose-response):liver/cathepsin D: control 32.75+/-3Gr2 64.5+/-5.86, P=0.001Gr3 62.41+/-5.14Gr4 61.41+/-5.72, P=0.01Gr5 37.91+/-3.18, P=0.001Gr6 37.08+/-3.04, P=0.001Gr736.83+/-3.12, P=0.001Liver/acidphosphatase: control 7.04+/-0.62Gr2 19.86+/-1.84, P=0.001Gr3 18.21+/-1.73Gr4 14.76+/-1.33, P=0.01Gr5 9.61+/-0.88, P=0.001Gr6 10+/-0.91, P=0.001Gr7 9.57+/-0.87, P=0.001Kidney/ cathepsinD: Control 48.38+/-4.15Gr2 76.3+/-7.11, P=0.001Gr3 74.85+/-6.96, P=0.05Gr4 73.81+/-6.54, P=0.01Gr5 53.49+/-4.86, P=0.001Gr6 52.4+/-4.67, P=0.001Gr7 52.87+/-4.92, P=0.001Kidney/ acidphosphatase: control 2.7+/-0.13Gr2 5.63+/-0.41, P=0.001Gr3 5.32+/-0.47 P=0.01Gr4 5.27+/-0.46 P=0.01Gr5 3.02+/-0.27, P=0.001Gr6 3.05+/-0.29, P=0.001Gr7 2.94+/-0.22, P=0.001. KEYWORDS CLASSIFICATION: 9,10-Dimethyl-1,2-benzanthracene;Animals;Antineoplastic Agents;Antineoplastic Agents,Phytogenic;Biological Markers;Body Weight;chemically induced;Carcinogens;drug effects;drug therapy;dietary modulation of cancer & cancer biomarkers;Dose-Response Relationship,Drug;enzymology;Female;Glycoproteins;India;Kidney;Liver;Lysosomes;Mammary Neoplasms,Experimental;mechanisms of carcinogenesis;Organ Size;pharmacology;Plant Extracts;Rats;Rats,Sprague-Dawley.
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