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AuthorsDuarte, Eliza Carla Barroso
da Silva, Marina Sena Lopes
Gomez, Marcus Vinícius
Gomez, Ricardo Santiago
MetadataShow full item record
AbstractBACKGROUND: Molecular epidemiological studies have now provided evidence that an individual susceptibility to cancer is mediated by genetic and environmental factors. Genetic polymorphisms have been described for enzymes involved in the metabolism of tobacco carcinogens and cancer risk is determined by the degree of expression and/or activity of enzymes involved in carcinogen activation or deactivation. The objective of this study was to investigate the GSTM1 null polymorphism and the risk for oral leukoplakia in individuals with tobacco-smoking habit in a Brazilian population. METHODS: A total of 52 tobacco-smoking patients with oral leukoplakia and 52 tobacco-smoking controls were recruited in a Brazilian population. The GSTM1 genotypes were studied by polymerase chain reaction-based methods. RESULTS: The frequency of the GSTM1 null genotype in the group with oral leukoplakia (57.7%) was statistically different from the controls (34.6%; OR: 2.57, 95% CI: 1.16-5.69, P < 0.05). The stratification of the samples according to the level of dysplasia showed increased prevalence of GSTM1 null genotype on lesions with moderate/severe histological dysplasia (68.2%) compared with the control group (31.9%). This difference was statistically significant (OR: 4.59, 95% CI: 1.29-16.33, P < 0.05). CONCLUSION: In conclusion, the GSTM1 null genotype may increase the risk for oral leukoplakia development.
CitationJ. Oral Pathol. Med. 2006, 35 (4):202-205
DescriptionBiomarkers of individual susceptibility: field studiesBiomarker (including alleles if genetic): GSTM1 null polymorphismEffect studied (phenotype/pathology):oral leukoplakiaTissue/biological material/sample size:oral swabs/subjectMethod of analysis:PCR Study design: case-controlStudy size: 52 patients-smokers, 52 healthy smokersImpact on outcome (including dose-response):cases with the polymorphism 34.6% versus control, OR 2.57, CI 95% 1.16-5.69, P<0.05. KEYWORDS CLASSIFICATION: Adult;Aged;Aged,80 and over;biomarkers of individual susceptibility: field studies;Brazil;Case-Control Studies;enzymology;Female;genetics;Glutathione;Glutathione Transferase;Humans;Leukoplakia,Oral;metabolism;methods;Male;Middle Aged;Polymerase Chain Reaction;Polymorphism,Genetic;Research;Smoking;field studies;genetic;analysis.
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