First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsDen Hond, Elly
Koch, Holger M
Schindler, Birgit K
Knudsen, Lisbeth E
Mørck, Thit A
Gutleb, Arno C
Fischer, Marc E
Reis, M Fátima
Gurzau, Anca Elena
Tratnik, Janja Snoj
AffiliationFlemish Institute for Technological Research (VITO), Mol, Belgium; University of Leuven, Leuven, Belgium; Umweltbundesamt (UBA), Berlin, Germany; Instituto de Salud Carlos III, Majadahonda (Madrid), Spain; nstitute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany; Public Health England, Chilton, United Kingdom; Environmental Health Sciences International, Hulst, the Netherlands; Jožef Stefan Institute, Ljubljana, Slovenia; University of Copenhagen, Copenhagen, Denmark; BiPRO GmbH, Munich, Germany; Federal Public Service (FPS) Health, Food Chain Safety and Environment, Brussels, Belgium; State General Laboratory, Nicosia, Cyprus; Paediatric Clinic, Larnaca General Hospital, Larnaca, Cyprus; National Institute of Public Health, Praha, Czech Republic; National Institute of Environmental Health, Budapest, Hungary; Health Service Executive, Dublin, Ireland; Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg; Laboratoire National de Santé, Dudelange, Luxembourg; Nofer Institute of Occupational Medicine, Lodz, Poland; Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; Environmental Health Center, Cluj-Napoca, Romania; Urad Verejneho Zdravotnictva Slovenskej Republiky, Bratislava, Slovakia; Karolinska Institutet, Stockholm, Sweden; Federal Office of Public Health (FOPH), Bern, Switzerland; University of Antwerp, Antwerpen, Belgium; University of Southern Denmark, Odense, Denmark
MetadataShow full item record
AbstractFor Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health.
We developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe.
In 17 European countries, we measured mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of 1,844 children (5-11 years of age) and their mothers. Specimens were collected over a 5-month period in 2011-2012. We obtained information on personal characteristics, environment, and lifestyle. We used the resulting database to compare concentrations of exposure biomarkers within Europe, to identify determinants of exposure, and to compare exposure biomarkers with health-based guidelines.
Biomarker concentrations showed a wide variability in the European population. However, levels in children and mothers were highly correlated. Most biomarker concentrations were below the health-based guidance values.
We have taken the first steps to assess personal chemical exposures in Europe as a whole. Key success factors were the harmonized protocol development, intensive training and capacity building for field work, chemical analysis and communication, as well as stringent quality control programs for chemical and data analysis. Our project demonstrates the feasibility of a Europe-wide human biomonitoring framework to support the decision-making process of environmental measures to protect public health.
CitationEnviron. Health Perspect. 2015, 123 (3):255-63
Sponsorsthe European Community’s Seventh Framework Programme [FP7/2007–2013] under grant agreement 244237. DEMOCOPHES (DEMOnstration of a study to C Oordinate and Perform Human biomonitoring on a European Scale) was co-funded (50%:50%) by the European Commission LIFE+ Programme (LIFE09/ENV/BE/000410) and the partners.
The following license files are associated with this item:
- Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach.
- Authors: Schwedler G, Seiwert M, Fiddicke U, Ißleb S, Hölzer J, Nendza J, Wilhelm M, Wittsiepe J, Koch HM, Schindler BK, Göen T, Hildebrand J, Joas R, Joas A, Casteleyn L, Angerer J, Castano A, Esteban M, Schoeters G, Den Hond E, Sepai O, Exley K, Bloemen L, Knudsen LE, Kolossa-Gehring M
- Issue date: 2017 Jun
- The Danish contribution to the European DEMOCOPHES project: A description of cadmium, cotinine and mercury levels in Danish mother-child pairs and the perspectives of supplementary sampling and measurements.
- Authors: Mørck TA, Nielsen F, Nielsen JK, Jensen JF, Hansen PW, Hansen AK, Christoffersen LN, Siersma VD, Larsen IH, Hohlmann LK, Skaanild MT, Frederiksen H, Biot P, Casteleyn L, Kolossa-Gehring M, Schwedler G, Castaño A, Angerer J, Koch HM, Esteban M, Schoeters G, Den Hond E, Exley K, Sepai O, Bloemen L, Joas R, Joas A, Fiddicke U, Lopez A, Cañas A, Aerts D, Knudsen LE
- Issue date: 2015 Aug
- The European COPHES/DEMOCOPHES project: towards transnational comparability and reliability of human biomonitoring results.
- Authors: Schindler BK, Esteban M, Koch HM, Castano A, Koslitz S, Cañas A, Casteleyn L, Kolossa-Gehring M, Schwedler G, Schoeters G, Hond ED, Sepai O, Exley K, Bloemen L, Horvat M, Knudsen LE, Joas A, Joas R, Biot P, Aerts D, Lopez A, Huetos O, Katsonouri A, Maurer-Chronakis K, Kasparova L, Vrbík K, Rudnai P, Naray M, Guignard C, Fischer ME, Ligocka D, Janasik B, Reis MF, Namorado S, Pop C, Dumitrascu I, Halzlova K, Fabianova E, Mazej D, Tratnik JS, Berglund M, Jönsson B, Lehmann A, Crettaz P, Frederiksen H, Nielsen F, McGrath H, Nesbitt I, De Cremer K, Vanermen G, Koppen G, Wilhelm M, Becker K, Angerer J
- Issue date: 2014 Jul
- Pilot study testing a European human biomonitoring framework for biomarkers of chemical exposure in children and their mothers: experiences in the UK.
- Authors: Exley K, Aerts D, Biot P, Casteleyn L, Kolossa-Gehring M, Schwedler G, Castaño A, Angerer J, Koch HM, Esteban M, Schindler BK, Schoeters G, Den Hond E, Horvat M, Bloemen L, Knudsen LE, Joas R, Joas A, Sepai O
- Issue date: 2015 Oct
- Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries.
- Authors: Smolders R, Den Hond E, Koppen G, Govarts E, Willems H, Casteleyn L, Kolossa-Gehring M, Fiddicke U, Castaño A, Koch HM, Angerer J, Esteban M, Sepai O, Exley K, Bloemen L, Horvat M, Knudsen LE, Joas A, Joas R, Biot P, Aerts D, Katsonouri A, Hadjipanayis A, Cerna M, Krskova A, Schwedler G, Seiwert M, Nielsen JK, Rudnai P, Közepesy S, Evans DS, Ryan MP, Gutleb AC, Fischer ME, Ligocka D, Jakubowski M, Reis MF, Namorado S, Lupsa IR, Gurzau AE, Halzlova K, Fabianova E, Mazej D, Tratnik Snoj J, Gomez S, González S, Berglund M, Larsson K, Lehmann A, Crettaz P, Schoeters G
- Issue date: 2015 Aug