• Scintigraphic assessment of renal function in steel plant workers occupationally exposed to lead.

      Wrońska-Nofer, Teresa; Pisarska, Anna; Trzcinka-Ochocka, Małgorzata; Hałatek, Tadeusz; Stetkiewicz, Jan; Braziewicz, Janusz; Nofer, Jerzy-Roch; Wąsowicz, Wojciech; Nofer Institute of Occupational Medicine, Lodz, Poland; Holycross Cancer Center, Poland; Institute of Physics, Jan Kochanowski University, Poland; Center for Laboratory Medicine, University Hospital Münster, Germany (2015-04-25)
      Occupational exposure to lead may produce kidney damage, but existing data on the dose range associated with nephrotoxicity are inconclusive. We here assessed renal function under conditions of low to moderate lead exposure using renal scintigraphy.
    • Screening survey of ocular, nasal, respiratory and skin symptoms in manicurists in Poland.

      Kieć-Świerczyńska, Marta; Świerczyńska-Machura, Dominika; Chomiczewska-Skóra, Dorota; Kręcisz, Beata; Walusiak-Skorupa, Jolanta; Nofer Institute of Occupational Medicine, Łódź, Poland (2017-10-06)
      Manicurists are exposed to various chemicals in nail and skin care products and may develop ocular, nasal, respiratory or skin adverse reactions to them. To investigate the occurrence of ocular, nasal, respiratory and skin problems among manicurists and to identify their causal factors, particularly allergic etiology and occupational origin.
    • Screening value of V-RQOL in the evaluation of occupational voice disorders.

      Morawska, Joanna; Niebudek-Bogusz, Ewa; Wiktorowicz, Justyna; Sliwinska-Kowalska, Mariola; Nofer Institute of Occupational Medicine, Lodz, Poland (2017-12-28)
      Given the growing number of occupational voice users, easy and quick broad-scale screening is necessary to provide prophylaxis of voice disorders. The aim of the study was to assess applicability of the Voice Related Quality of Life questionnaire (V-RQOL) to screening occupational voice disorders.
    • Sense of Coherence, Smoking Status, Biochemical Cardiovascular Risk Factors and Body Mass in Blue Collar Workers-Short Report.

      Najder, Anna; Nofer Institute of Occupational Medicine, Lodz, Poland (2018-01-01)
      The crucial cause of cardiovascular disorders is atherosclerosis developed by abnormal cholesterols levels or disorders affecting blood glucose. One of the best-known cardiovascular risk factors is also tobacco smoking. Simultaneously, sense of coherence (SoC) as a personal resource motivating to managing one's own health behaviors, such as avoiding tobacco smoking, was reported to be protective against coronary heart disease. Such association was observed in white-collar workers but not in blue-collar workers. According to the above, the present article aims to establish relationships between SoC, smoking behaviors, biochemical markers (BM): lipids and glucose levels and body mass index (BMI) in blue-collar workers. Sense of Coherence Questionnaire (SOC-29), fasting blood test, and BMI were used to assess such relationships. The study group consisted of 304 Polish males working 8-hr shifts in a 4-brigade rotating system. The analysis revealed that SoC level did not differ depending on smoking behavior. The analysis also showed no differences in BMI and BM depending on SoC. Concerning smoking status, the study group was divided into three subgroups which differed regarding triglycerides and glucose levels. The present findings considering SoC indicate that any psychological construct should not be studied separately because probably only some sets of different features may influence one's behavior and BM as well.
    • Sensitization to occupational allergens in hairdressing apprentices diagnosed already before entering vocational training.

      Golińska-Zach A.; Krawczyk-Szulc P.; Wiszniewska, Marta; Nowakowska-Świrta E.; Świerczyńska-Machura D.; Tymoszuk D.; Walusiak-Skorupa, Jolanta; Nofer Institute of Occupational Medicine, Lodz, Poland (2016)
      Background: Hairdressers are occupationally exposed to many allergenic and irritating substances. Additionally, hairdressing apprentices are exposed to the same allergens as professional hairdressers, due to the fact that vocational training starts in the beginning of the education. This study was undertaken to investigate early occurrence of sensitization to occupational allergens in hairdressing apprentices before the onset of the vocational training. Material and Methods: Three hundred and seven hairdressing apprentices were assessed using a questionnaire and skin prick tests (SPTs) to common and occupational allergens. The level of total and serum specific immunoglobulin E (IgE) to occupational allergens was evaluated and spirometry was performed. Results: At least one skin and/or respiratory and/or conjunctival symptom was reported by 29.9% of subjects. Among subjects with at least one symptom, 28.2% of them were atopic whereas among 43.4% of them total IgE level was elevated. Atopy was found in 20% cases. In the case of one apprentice, positive SPT for paraphenylenediamine was found. Nearly 33% of apprentices had elevated total IgE level and 5 of them had specific IgE for occupational allergens. Conclusions: The study revealed that hairdressing apprentices might be sensitized to occupational allergens even before the beginning of vocational training, due to prior non-professional exposure to hairdressing agents. Furthermore, many of them report skin, respiratory and conjunctival symptoms, often connected with chronic disease diagnosis. Thus, candidates for hairdressers should be examined thoroughly before the start of the education and tests for allergy to hairdressing substances are indicated.
    • Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium.

      Santonen, Tiina; Alimonti, Alessandro; Bocca, Beatrice; Duca, Radu Corneliu; Galea, Karen S; Godderis, Lode; Göen, Thomas; Gomes, Bruno; Hanser, Ogier; Iavicoli, Ivo; et al. (2019-10-01)
      The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure to relevant priority chemicals and developing new approaches for occupational biomonitoring. In this manuscript, the hexavalent chromium [Cr(VI)] study design is presented as the first example of this HBM4EU approach. This study involves eight European countries and plans to recruit 400 workers performing Cr(VI) surface treatment e.g. electroplating or stainless steel welding activities. The aim is to collect new data on current occupational exposure to Cr(VI) in Europe and to test new methods for Cr biomonitoring, specifically the analysis of Cr(VI) in exhaled breath condensate (EBC) and Cr in red blood cells (RBC) in addition to traditional urinary total Cr analyses. Furthermore, exposure data will be complemented with early biological effects data, including genetic and epigenetic effects. Personal air samples and wipe samples are collected in parallel to help informing the biomonitoring results. We present standard operational procedures (SOPs) to support the harmonized methodologies for the collection of occupational hygiene and HBM samples in different countries.
    • Sex-Dependent Impact of Low-Level Lead Exposure during Prenatal Period on Child Psychomotor Functions.

      Polanska, Kinga; Hanke, Wojciech; Pawlas, Natalia; Wesolowska, Ewelina; Jankowska, Agnieszka; Jagodic, Marta; Mazej, Darja; Dominowska, Jolanta; Grzesiak, Mariusz; Mirabella, Fiorino; et al. (2018-10-16)
      The impact of exposure to lead on child neurodevelopment has been well established. However, sex differences in vulnerability are still not fully explained. We aimed at evaluating the effect of a low-level lead exposure, as measured between 20 to 24 weeks of pregnancy and in cord blood, on developmental scores up to 24 months of age in 402 children from the Polish Mother and Child Cohort (REPRO_PL). Additionally, sex-dependent susceptibility to lead at this very early stage of psychomotor development was assessed. The blood lead levels were analyzed using inductively coupled plasma mass spectrometry (ICP-MS). In order to estimate the children's neurodevelopment, the Bayley Scales of Infant and Toddler Development was applied. The geometric mean (GM) for blood lead level during 20⁻24 weeks of pregnancy was 0.99 ± 0.15 µg/dL and, in the cord blood, it was 0.96 ± 0.16 µg/dL. There was no statistically significant impact of lead exposure during prenatal period on the girls' psychomotor abilities. Among the boys, we observed lower scores for cognitive functions, along with increasing cord blood lead levels (β = -2.07;
    • Sleep quality and methylation status of selected tumor suppressor genes among nurses and midwives.

      Bukowska-Damska, Agnieszka; Reszka, Edyta; Kaluzny, Pawel; Wieczorek, Edyta; Przybek, Monika; Zienolddiny, Shanbeh; Peplonska, Beata; Nofer Institute of Occupational Medicine (2018)
      Chronic sleep restriction may affect metabolism, hormone secretion patterns and inflammatory responses. Limited reports suggest also epigenetic effects, such as changes in DNA methylation profiles. The study aims to assess the potential association between poor sleep quality or sleep duration and the levels of 5-methylcytosine in the promoter regions of selected tumor suppressor genes. A cross-sectional study was conducted on 710 nurses and midwives aged 40-60 years. Data from interviews regarding sleep habits and potential confounders were used. The methylation status of tumor suppressor genes was determined via qMSP reactions using DNA samples derived from leucocytes. No significant findings were observed in the total study population or in the two subgroups of women stratified by the current system of work. A borderline significance association was observed between a shorter duration of sleep and an increased methylation level in CDKN2A among day working nurses and midwives. Further studies are warranted to explore this under-investigated topic.
    • Smoking and alcohol drinking during pregnancy as the risk factors for poor child neurodevelopment – A review of epidemiological studies.

      Polanska, Kinga; Jurewicz, Joanna; Hanke, Wojciech; Nofer Institute of Occupational Medicine, Lodz, Poland (2015)
      Maternal active and passive smoking and low or moderate alcohol drinking during pregnancy, taking into account the level of exposure and developmental or behavioral outcomes, are recognized as a significant issue from both a clinical and a public health perspective. The article aims at evaluating the impact of prenatal exposure to tobacco smoke constituents and low or moderate alcohol drinking during pregnancy on children neurodevelopment by reviewing the most recently published literature. Relevant studies were identified by searching the Pubmed, Medline and Ebsco literature databases. This review is restricted to 29 human studies published in English in peer reviewed journals since 2006. The studies published recently continued to show some relationship between tobacco smoke exposure, from active and passive maternal smoking during pregnancy, and children’s psychomotor development independent of other variables, but this relationship is not straightforward. The association is mostly consistent for measures of academic achievements and behavioral problems which require further attention. The results of the studies on low or moderate exposure to alcohol are not fully conclusive, but some of them suggest that consumption of alcohol during pregnancy may adversely affect children’s intelligence quotient (IQ), mental health, memory and verbal or visual performance. As the reviewed studies indicate, maternal lifestyle during pregnancy like alcohol drinking or smoking may affect children neurodevelopment. All effort should be taken to eliminate such exposure to ensure appropriate children’s development.
    • Smoking at workplace – Legislation and health aspect of exposure to second-hand tobacco smoke

      Lipinska-Ojrzanowska, Agnieszka; Polanska, Kinga; Wiszniewska, Marta; Kleniewska, Aneta; Dörre-Kolasa, Dominika; Walusiak-Skorupa, Jolanta; Nofer Institute of Occupational Medicine, Lodz, Poland; Jagiellonian University, Kraków, Poland (2015)
      Tobacco smoke contains thousands of xenobiotics harmful to human health. Their irritant, toxic and carcinogenic potential has been well documented. Passive smoking or exposure to second-hand smoke (SHS) in public places, including workplace, poses major medical problems. Owing to this fact there is a strong need to raise workers’ awareness of smoking-related hazards through educational programs and to develop and implement legislation aimed at eliminating SHS exposure. This paper presents a review of reports on passive exposure to tobacco smoke and its impact on human health and also a review of binding legal regulations regarding smoking at workplace in Poland. It has been proved that exposure to tobacco smoke during pregnancy may lead to, e.g., preterm delivery and low birth weight, sudden infant death syndrome, lung function impairment, asthma and acute respiratory illnesses in the future. Exposure to tobacco smoke, only in the adult age, is also considered as an independent risk factor of cardiovascular diseases, acute and chronic respiratory diseases and cancer. Raising public awareness of tobacco smoke harmfulness should be a top priority in the field of workers’ health prevention. Occupational medicine physicians have regular contacts with occupationally active people who smoke. Thus, occupational health services have a unique opportunity to increase employees and employers’ awareness of adverse health effects of smoking and their prevention.
    • Smoking Patterns and Smoking Cessation Willingness-A Study among Beneficiaries of Government Welfare Assistance in Poland.

      Milcarz, Katarzyna; Makowiec-Dabrowska, Teresa; Bak-Romaniszyn, Leokadia; Kaleta, Dorota; Nofer Institute of Occupational Medicine, Łódź, Poland (2017-01-27)
      This study examines the prevalence and tobacco use patterns among adult social assistance beneficiaries and their interest in quitting. The results are based on data collected in a cross-sectional survey conducted among adults in the Piotrkowski district. A sample of 3636 social assistance beneficiaries produced a total of 1817 respondents who completed face-to-face questionnaires. Overall, 37.1% of the respondents, including 52.8% men and 29.6% women, were current smokers. Over one third of the smokers reported their willingness to quit. In the study population, several characteristics were significantly associated with the current daily smoking: male gender, low educational attainment, unemployment or temporary employment, lack of awareness of smoking-associated health risks, use of e-cigarettes, and exposure to environmental tobacco smoke (ETS). The intention to quit smoking among the daily smokers was positively correlated with their awareness of smoking-associated health risks, lack of previous quit attempts, and low exposure to ETS. Smoking prevalence among social assistance recipients tends to be higher than in the general population, but more than half of the smokers are willing to quit. There is an urgency to develop policies tailored to the needs of these disadvantaged population groups.
    • Socio-demographic predictors of person-organization fit.

      Merecz-Kot, Dorota; Andysz, Aleksandra; Nofer Institute of Occupational Medicine, Łódź, Poland (2017-02-21)
      The aim of this study was to explore the relationship between socio-demographic characteristics and the level of complementary and supplementary person-organization fit (P-O fit).
    • Sociodemographic determinants for initiation and duration of breastfeeding - Polish Mother and Child Cohort Study

      Kwarta, Paulina; Polanska, Kinga; Jerzyńska, Joanna; Stelmach, Wlodzimierz; Krakowiak, Jan; Karbownik, Michał; Król, Anna; Hanke, Wojciech; Stelmach, Iwona; Nofer Institute of Occupational Medicine (2018-12-05)
    • Sociodemographic, Lifestyle, Environmental and Pregnancy-Related Determinants of Dietary Patterns during Pregnancy.

      Wesołowska, Ewelina; Jankowska, Agnieszka; Trafalska, Elżbieta; Kałużny, Paweł; Grzesiak, Mariusz; Dominowska, Jolanta; Hanke, Wojciech; Calamandrei, Gemma; Polańska, Kinga; Nofer Institute of Occupational Medicine (2019-03-02)
      Characterization of dietary patterns represents a valid and meaningful measure of overall diet quality and nutrient intake. The study aims at evaluating the sociodemographic, lifestyle, environmental, and pregnancy-related determinants of maternal dietary patterns during pregnancy.
    • Solving the problem of smoking in the Polish enterprises during 2003-2015.

      Korzeniowska, Elzbieta; Puchalski, Krzysztof; Nofer Institute of Occupational Medicine, Lodz, Poland (2018-01-15)
      Tobacco smoking is a major organizational, economical, and public relations-related (PR-related) problem for the company. Moreover, it is an important health determinant of the working population. The paper reports the results of the research which analyzed the current state and the tobacco control activities' transformations undertaken by Polish employers between 2003 and 2015.
    • Spirometric and hygienic criteria in recognition of occupational COPD in Poland - A retrospective analysis of medical records.

      Kleniewska, Aneta; Walusiak-Skorupa, Jolanta; Lipinska-Ojrzanowska, Agnieszka; Szczesniak, Kamila; Wiszniewska, Marta; Nofer Institute of Occupational Medicine, Łódź, Poland (2017-11-03)
      Chronic obstructive pulmonary disease (COPD) may be work-related. It has been estimated that 15% of the population burden of COPD is attributable to occupational exposure. However, in Poland COPD is rarely recognized as an occupational disease. The aim of the study has been to analyze the causes of the low prevalence of work-related COPD in the context of the existing criteria as well as to analyze which part of the assessment - clinical or hygienic one - is responsible for such a low rate of occupational COPD recognitions.
    • Społeczne czynniki ryzyka nadwagi i otyłości oraz ich profilaktyka w zakładzie pracy.

      Instytut Medycyny Pracy. Krajowe Centrum Promocji Zdrowia w Miejscu Pracy; Nofer Institute of Occupational Medicine, Łódź, Poland (2017)
      Głównym problemem zdrowotnym, który dotyka pracowników różnych grup zawodowych, jest nieprawidłowy wskaźnik masy ciała.
    • A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis.

      Abraham, Miriam; Alramadhan, Salem; Iniguez, Carmen; Duijts, Liesbeth; Jaddoe, Vincent W V; Den Dekker, Herman T; Crozier, Sarah; Godfrey, Keith M; Hindmarsh, Peter; Vik, Torstein; et al. (2017)
      Maternal smoking during pregnancy is linked to reduced birth weight but the gestation at onset of this relationship is not certain. We present a systematic review of the literature describing associations between maternal smoking during pregnancy and ultrasound measurements of fetal size, together with an accompanying meta-analysis.
    • Takotsubo cardiomyopathy in the case of 72-year-old teacher after work-related psychological stress. Evolution of left ventricular longitudinal strain - Delayed but complete recovery in automated function imaging (AFI).

      Wierzbowska-Drabik, Karina; Marcinkiewicz, Andrzej; Hamala, Piotr; Trzos, Ewa; Lipiec, Piotr; Kurpesa, Małgorzata; Krecki, Radosław; Plewka, Michał; Kasprzak, Jarosław D.; Nofer Institute of Occupational Medicine, Łódź, Poland (2017-06-19)
      Takotsubo cardiomyopathy (TC) is related to a transient systolic dysfunction of left ventricle (LV), accompanied by clinical and electrocardiographic symptoms of myocardial ischemia in the absence of hemodynamically significant coronary artery disease. Takotsubo cardiomyopathy is usually provoked by a psychologically or/and physically stressful event which may be related to occupational activities. Although visually assessed evolution of LV function is well documented, the data concerning strain changes is sparse and various patterns of deformation abnormalities are suggested. We have described a 72-year-old woman with chest pain related to a lecture given at the meeting of the Senior University, fulfilling all the Mayo Clinic criteria of the TC. The longitudinal strain analysis with automated function imaging (AFI) documented severe impairment and stepwise recovery of regional and global LV contractility. The case described confirms that accurate diagnosis, treatment and documenting of functional improvement in takotsubo cardiomyopathy may enable the return to occupational activities even for elderly persons. Int J Occup Med Environ Health 2017;30(4):681-683.
    • [Ten years of the application of REACH and CLP - assessing the knowledge and implementation of these regulations by Polish users of chemicals].

      Konieczko, Katarzyna; Czerczak, Sławomir; Kupczewska-Dobecka, Małgorzata; Nofer Institute of Occupational Medicine (2019-07-16)
      Wstęp: Celem pracy było przeprowadzenie oceny świadomości dalszych użytkowników i dystrybutorów chemikaliów w Polsce na temat obowiązujących regulacji prawnych [rozporządzenia dotyczącego rejestracji, oceny i udzielania zezwoleń w zakresie chemikaliów (Registration, Evaluation, Authorisation and Restriction of Chemicals − REACH) i rozporządzenia w sprawie klasyfikacji, oznakowania i pakowania (classification, labelling and packaging − CLP)] w zakresie chemikaliów oraz określenie na tej podstawie potrzeby szkoleń i akcji informacyjnych skierowanych do tych grup zawodowych za pomocą badania ankietowego. Materiał i metody: Do przeprowadzenia ankiety wybrano internetowe oprogramowanie SurveyMonkey. Badaniami objęto 2 grupy respondentów. Pierwszą grupę osób, do których skierowano ankietę, stanowili dalsi użytkownicy i dystrybutorzy substancji chemicznych i ich mieszanin, 2 grupę – konsumenci. Wyniki: Uzyskano odpowiedzi od 65 dalszych użytkowników i dystrybutorów chemikaliów oraz od 98 konsumentów. Aż 23% respondentów nie znało obowiązków, jakie nakładają na ich przedsiębiorstwo rozporządzenia REACH i CLP. Ponad 59% badanych (dalszych użytkowników i dystrybutorów) nie miało możliwości uczestniczenia w szkoleniach dotyczących zarządzania bezpieczeństwem chemicznym w ostatnich 5 latach. Osiemdziesiąt procent respondentów było zainteresowanych uczestnictwem w nieodpłatnych kursach umożliwiających poszerzenie wiedzy z zakresu klasyfikacji, oznakowania i wprowadzania chemikaliów do obrotu. Wnioski: Pomimo 10 lat obowiązywania REACH i CLP wiele osób pracujących w przedsiębiorstwach nadal nie zna obowiązków swojej firmy określonych w tych rozporządzeniach. Odsetek pracowników pozytywnie oceniających swoje kompetencje rośnie wraz z wielkością przedsiębiorstwa. Wyniki badania ankietowego wskazują na potrzebę organizowania ustawicznych szkoleń dla osób stosujących chemikalia w działalności zawodowej oraz dla dystrybutorów. Bardzo istotne jest przeszkolenie na podstawowym poziomie dystrybutorów chemikaliów. Szkolenia powinny zapewnić im elementarną wiedzę na temat zagrożeń stwarzanych przez chemikalia, tak aby mogli te informacje w przystępny sposób przekazać konsumentom