• Identification of cross-reactive carbohydrate determinants in subjects reporting work-related respiratory symptoms.

      Wiszniewska, Marta; Zgorzelska-Kowalik, Joanna; Nowakowska-Swirta, Ewa; Walusiak-Skorupa, Jolanta; Nofer Institute of Occupational Medicine, Łódź, Poland (2015-02-28)
      Objectives: The role of cross-reactive carbohydrate determinants (CCDs) in diagnostics of occupational allergy remains unclarified and its clinical relevance is still questioned. The aim of the study was to assess the frequency of positive response to CCDs in the subjects with suspected occupational allergy and the relationship between other diagnostic test results and final diagnosis. Material and Methods: The study group included 201 patients. They underwent clinical examination, skin prick test (SPT) to common and occupational allergens, specific serum immunoglobulin (sIgE) determinations, spirometry and specific inhalation challenge test. Moreover, sIgE to CCDs from bromelain was assessed in all subjects. Results: Occupational respiratory allergy was recognized in 64.3% of CCD-positive and 52.4% of CCD-negative patients. Positive SPT results to common and occupational allergens were found in 64.3% and 35.7% of CCD-positive subjects, respectively. In all subjects with CCDs, the sIgE to grass pollens as well as to occupational allergens were detected. The total IgE level > 100 kU/l was significantly associated with the presence of sIgE to CCDs. Conclusions: sIgE to CCDs were found in 7% of subjects suspected to suffer from occupational respiratory allergy. The presence of CCDs is not significantly associated with occupational respiratory allergy. It is also not more frequent in subjects reporting work-related respiratory symptoms in whom occupational allergy was not confirmed. The elevated total IgE level was related with CCD positivity. In patients with suspected occupational allergy, the presence of sIgE to CCDs in serum did not indicate the irrelevance of positive sIgE to occupational allergens.
    • Identification of shared risk loci and pathways for bipolar disorder and schizophrenia.

      Forstner, Andreas J; Hecker, Julian; Hofmann, Andrea; Maaser, Anna; Reinbold, Céline S; Mühleisen, Thomas W; Leber, Markus; Strohmaier, Jana; Degenhardt, Franziska; Treutlein, Jens; et al. (2017)
      Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (p = 1.46x10-8). This provides further evidence that SCZ-associated loci contribute to the development of BD. Two SNPs remained significant after Bonferroni correction. The most strongly associated SNP was located near TRANK1, which is a reported genome-wide significant risk gene for BD. Pathway analyses for all shared SCZ-BD SNPs revealed 25 nominally enriched gene-sets, which showed partial overlap in terms of the underlying genes. The enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. The present data provide further insights into shared risk loci and disease-associated pathways for BD and SCZ. This may suggest new research directions for the treatment and prevention of these two major psychiatric disorders.
    • Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

      Ji, Xuemei; Bossé, Yohan; Landi, Maria Teresa; Gui, Jiang; Xiao, Xiangjun; Qian, David; Joubert, Philippe; Lamontagne, Maxime; Li, Yafang; Gorlov, Ivan; et al. (2018-08-13)
      Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
    • Impedance cardiography – Old method, new opportunities. Part I. Clinical applications.

      Siedlecka, Jadwiga; Siedlecki, Patryk; Bortkiewicz, Alicja; Nofer Institute of Occupational Medicine, Łódź, Poland; Medical University of Lodz, Łódź, Poland (2015-02-28)
      Monitoring of cardiovascular hemodynamic changes requires a very expensive and highly specialized equipment and skilled medical personnel. Up to the present time, an inexpensive, non-invasive and easy-to-use method which, like Doppler echocardiography, magnetic resonance angiography or radionuclide imaging, would assess hemodynamics of the cardiovascular system was not available. A method known as impedance cardiography (ICG) or thoracic electrical bioimpedance cardiography (TEBC) meets those criteria. It is non-invasive, which is of a particular advantage over the conventional methods that require catheterization. As a result, the patient is not at risk of possible complications and the procedure is less expensive and easier. Impedance cardiography, despite its non-invasive character, has not been so far extensively used for monitoring of hemodynamic parameters in hospitalized patients. Various authors report that attempts have been continued to compare the results from ICG and those obtained by other diagnostic methods. This paper presents the use of impedance cardiography in diagnosis of hypertension, cardiac insufficiency, differentiating the causes of acute dyspnea, as well as in assessing the effects of cardiac rehabilitation in patients with heart failure.
    • Impedance cardiography – Old method, new opportunities. Part II. Testing of cardiovascular response to various factors of work environment.

      Siedlecka, Jadwiga; Siedlecki, Patryk; Bortkiewicz, Alicja; Nofer Institute of Occupational Medicine, Łódź, Poland; Medical University of Lodz, Łódź, Poland (2015-02-28)
      Impedance cardiography seems to be a very good, although underappreciated diagnostic method. What may distinguish it from among the many research methods is the fact that it enables non-invasive monitoring of cardiac output, stroke volume and systemic vascular resistance. Holter recording of the hemodynamic parameters makes it possible to study them not only in stationary (hospital, outpatient clinic) conditions, but also during household or professional activities, e.g., during road vehicle driving. Assessment of the trends of changes in the circulatory system of the employee at work makes it possible to judge whether the type of work performed by the worker is well tolerated – whether it is not too hard or too stressful. This is important, therefore, impedance cardiography can be extensively used in occupational medicine. Provision of preventive care to workers according to current standards requires, on the one hand, the use of the latest diagnostic methods while, on the other hand, the methods must be inexpensive, because otherwise the employer would not be able or willing to pay the associated costs. Impedance cardiography meets those criteria; however, few data is available in literature worldwide on the use of this method in the research on the impact of occupational work on cardiovascular responses of the employees. This work reports the use of impedance cardiography in studies on the various aspects of work environment.
    • Implementation of smoke-free homes in Poland.

      Kaleta, Dorota; Fronczak, Adam; Usidame, Bukola; Dziankowska-Zaborszczyk, Elżbieta; Makowiec-Dabrowska, Teresa; Wojtysiak, Piotr; Medical University of Lodz, Poland; University of Massachusetts, Boston, USA; Nofer Institute of Occupational Medicine, Lodz, Poland; County Office, Piotrków Trybunalski, Poland (2016)
      Exposure to environmental tobacco smoke (ETS) constitutes a threat to the health of many people. In order to diminish ETS exposure, countries (including Poland) implemented legal restrictions of smoking in public places and worksites. Currently more attention is also paid to reduce overall and residential ETS exposure by voluntary smoke-free home policy adoption. The aim of current analysis was to evaluate the prevalence and determinants of implementing smoking bans at place of residence among economically active males and females in Poland.
    • In vitro and in vivo activity of cyclopeptide Dmt-c[d-Lys-Phe-Asp]NH2, a mu opioid receptor agonist biased toward β-arrestin.

      Gach-Janczak, Katarzyna; Piekielna-Ciesielska, Justyna; Adamska-Bartłomiejczyk, Anna; Wtorek, Karol; Ferrari, Federica; Calo', Girolamo; Szymaszkiewicz, Agata; Piasecka-Zelga, Joanna; Janecka, Anna; Nofer Institute of Occupational Medicine (2018-07)
      Morphine and related drugs, which are the most effective analgesics for the relief of severe pain, act through activating opioid receptors. The endogenous ligands of these receptors are opioid peptides which cannot be used as antinociceptive agents due to their low bioactivity and stability in biological fluids. The major goal of opioid research is to understand the mechanism of action of opioid receptor agonists in order to improve therapeutic utility of opioids. Analgesic effects of morphine are mediated mostly through activation of the mu opioid receptor. However, in the search for safer and more effective drug candidates, analogs with mixed opioid receptor profile gained a lot of interest. Recently, the concept of biased agonists able to differentially activate GPCR downstream pathways, became a new approach in the design of novel drug candidates. It is hypothesized that compounds promoting G-protein signaling may produce analgesia while β-arrestin recruitment may be responsible for opioid side effects. In this report we showed that replacement of the tyrosine residue in the mu-selective ligand Tyr-c[d-Lys-Phe-Asp]NH2 with 2',6'-dimethyltyrosine (Dmt) produced a cyclopeptide Dmt-c[d-Lys-Phe-Asp]NH2 with mu/delta opioid receptor agonist profile. This analog showed improved antinociception in the hot-plate test, probably due to the simultaneous activation of mu and delta receptors but also significantly inhibited the gastrointestinal transit. Using the bioluminescence resonance energy transfer (BRET) assay it was shown that this analog was a mu receptor agonist biased toward β-arrestin. β-Arrestin-dependent signaling is most likely responsible for the observed inhibition of gastrointestinal motility exerted by the novel cyclopeptide.
    • An in vivo biocompatibility study of surgical meshes made from bacterial cellulose modified with chitosan.

      Piasecka-Zelga, Joanna; Zelga, Piotr; Szulc, Joanna; Wietecha, Justyna; Ciechańska, Danuta; Nofer Institute of Occupational Medicine, Lodz, Poland (2018-05-18)
      Bacterial cellulose modified with chitosan (MBC) is an innovative biomaterial used in regenerative medicine which may potentially improve treatment outcomes mesh for hernia repair surgery by facilitating better absorption in native tissue with less risk of mesh-related infections. The aim of the present study was to evaluate the biocompatibility of mesh based on MBC, and determine whether immunological reactions occur due to hypersensitivity to the implants. Forty five Imp:WIST rats were randomly assigned to be implanted with one of three mesh types: simple polypropylene mesh (n = 15), mesh modified by bacterial cellulose only (n = 15) and MBC mesh (n = 15) and evaluated after one and three months following intramuscular implantation. For MBC mesh, basic toxicological studies, i.e. Acute Dermal Irritation, Intradermal Reactivity and Acute Sensitization (GPMT), were also carried out on 9 Imp:BN albino rabbits and 15 Imp:D-H guinea pigs. The lowest immune response and the highest degree of fibroplasia were observed for MBC mesh both after one and three months after implantation. Toxicological studies classified the tested MBC mesh as a barely perceptible irritant with no signs of sensitization or allergic reactions observed during the studies. The findings indicate that MBC mesh does not irritate, does not sensitize and does not cause hypersensitivity in the implant site, and therefore presents a low risk of provoking such reactions in humans.
    • Influence of dispersion medium on nanomaterial-induced pulmonary inflammation and DNA strand breaks: investigation of carbon black, carbon nanotubes and three titanium dioxide nanoparticles.

      Hadrup, Niels; Bengtson, Stefan; Jacobsen, Nicklas R; Jackson, Petra; Nocun, Marek; Saber, Anne T; Jensen, Keld A; Wallin, Håkan; Vogel, Ulla; Nofer Institute of Occupational Medicine, Lodz, Poland (2017-12-31)
      Intratracheal instillation serves as a model for inhalation exposure. However, for this, materials are dispersed in appropriate media that may influence toxicity. We tested whether different intratracheal instillation dispersion media influence the pulmonary toxicity of different nanomaterials. Rodents were intratracheally instilled with 162 µg/mouse/1620 µg/rat carbon black (CB), 67 µg/mouse titanium dioxide nanoparticles (TiO2) or 54 µg/mouse carbon nanotubes (CNT). The dispersion media were as follows: water (CB, TiO2); 2% serum in water (CB, CNT, TiO2); 0.05% serum albumin in water (CB, CNT, TiO2); 10% bronchoalveolar lavage fluid in 0.9% NaCl (CB), 10% bronchoalveolar lavage (BAL) fluid in water (CB) or 0.1% Tween-80 in water (CB). Inflammation was measured as pulmonary influx of neutrophils into bronchoalveolar fluid, and DNA damage as DNA strand breaks in BAL cells by comet assay. Inflammation was observed for all nanomaterials (except 38-nm TiO2) in all dispersion media. For CB, inflammation was dispersion medium dependent. Increased levels of DNA strand breaks for CB were observed only in water, 2% serum and 10% BAL fluid in 0.9% NaCl. No dispersion medium-dependent effects on genotoxicity were observed for TiO2, whereas CNT in 2% serum induced higher DNA strand break levels than in 0.05% serum albumin. In conclusion, the dispersion medium was a determinant of CB-induced inflammation and genotoxicity. Water seemed to be the best dispersion medium to mimic CB inhalation, exhibiting DNA strand breaks with only limited inflammation. The influence of dispersion media on nanomaterial toxicity should be considered in the planning of intratracheal investigations.
    • The influence of lidocaine topical anesthesia during transesophageal echocardiography on blood methemoglobin level and risk of methemoglobinemia.

      Filipiak-Strzecka, Dominika; Kasprzak, Jarosław Damian; Wiszniewska, Marta; Walusiak-Skorupa, Jolanta; Lipiec, Piotr; Department of Cardiology, Bieganski Hospital, Medical University of Lodz, Poland; Nofer Institute of Occupational Medicine, Lodz, Poland (2015-01)
      Methemoglobinemia is a relatively rare, but potentially life-threating medical condition, which may be induced by application of topical anaesthetic agents commonly used during endoscopic procedure. The aim of our study was to assess the influence of lidocaine used prior to transesophageal echocardiography (TEE) on the blood level of methemoglobin in vivo. Additionally we attempted to establish the occurrence rate of clinically evident lidocaineinduced methemoglobinemia on the basis of data collected in our institution. We retrospectively analyzed patient records from 3,354 TEEs performed in our echocardiographic laboratory over the course of 13 years in search for clinically evident methemoglobinemia cases. Additionally, 18 consecutive patients referred for TEE were included in the prospective part of our analysis. Blood samples were tested before and 60 min after pre-TEE lidocaine anesthesia application. Information concerning concomitant conditions and pharmacotherapy were also obtained. In 3,354 patients who underwent TEE in our institution no cases of clinically evident methemoglobinemia occurred. In the prospective part of the study, none of 18 patients [16 (89 %) men, mean age 63 ± 13] was diagnosed with either clinical symptoms of methemoglobinemia or exceeded normal blood concentration of methemoglobin. Initial mean methemoglobin level was 0.5 ± 0.1 % with mild, statistically (but not clinically) significant rise to 0.6 ± 0.1 % after 60 min (p = 0.02). Among the analyzed factors only the relation between the proton pump inhibitors intake and methemoglobin blood level rise was identified as statistically relevant (p = 0.03). In adults, pre-TEE lidocaine anesthesia with recommended dosage results in significant increase in methemoglobin blood level, which however does not exceed normal values and does not result in clinically evident methemoglobinemia.
    • Influence of spectral interferences on the results of quartz determination by infrared spectrometry

      Maciejewska, Aleksandra; Nofer Institute of Occupational Medicine, Lodz, Poland (2015)
      Wstęp: Metody oznaczania kwarcu oparte na technice spektrometrii w podczerwieni (Fourier transform infrared spectrometry – FTIR) nie są specyficzne – na otrzymywane wyniki wpływają składniki matrycy, których część jest przyczyną interferencji spektralnych. Celem pracy była ocena wpływu składników pyłów, które podczas oznaczeń z kwarcu powodują z nim interferencje spektralne oraz opracowanie sposobów minimalizowania skutków tych interferencji. Materiał i metody: Badania wpływu interferentów na wyniki oznaczeń kwarcu przeprowadzono z użyciem pyłów respirabilnych: kwarcu SRM 1878a, krystobalitu SRM 1879a, krzemionki bezpostaciowej syntetycznej (Zeosilu) oraz skalenia – albitu i kaolinitu. Do badań przygotowano 17 mieszanin kwarcu z interferentami w stężeniach 10–90%. Oznaczenia kwarcu prowadzono metodą pastylkową, z bromkiem potasu (KBr) jako nośnikiem. Wyniki: W mieszaninach kwarcu z interferentami wyniki jego oznaczeń na podstawie pasm 798–779 cm–1 były zawyżone średnio o 10–55%. Wyniki bardziej zbliżone do rzeczywistej zawartości kwarcu – z wyjątkiem mieszanin z kaolinitem – otrzymano, biorąc za podstawę oznaczeń pasmo 695 cm–1. Stwierdzono, że najlepszymi metodami zmniejszającymi wpływ interferencji spektralnych na wyniki oznaczeń kwarcu są: skalowane odejmowanie widm w przypadku występowania skaleni lub kaolinitu, jeśli badania z jego udziałem prowadzono w niespopielonych próbkach, krzywa korekcyjna dla kaolinitu w przypadku badań także niespopielonych próbek, obliczanie zawartości kwarcu na podstawie pasma 695 cm–1 w mieszaninach z krystobalitem, krzemionką bezpostaciową lub kaolinitem w próbkach spopielonych. Wnioski: Przeprowadzone badania wskazują na potrzebę identyfikowania interferencji spektralnych podczas oznaczania krystalicznej krzemionki metodą FTIR oraz konieczność podejmowania działań zmierzających do minimalizowania wpływu tych interferencji na otrzymywane wyniki.
    • Inhalable dust, endotoxins and (1–3)-β-d-glucans as indicators of exposure in waste sorting plant environment

      Kozajda, Anna; Jeżak, Karolina; Cyprowski, Marcin; Szadkowska-Stańczyk, Irena; Nofer Institute of Occupational Medicine, Łódź, Poland (2017-05-26)
      The aim of the study was to assess the levels of inhalable dust, endotoxins and (1–3)-b-Dglucans as agents harmful to the respiratory tract of workers of municipal waste sorting plants and interaction between these agents based on the measurements taken in two plants with different processing capacities. The study was conducted in summer season in two waste sorting plants (WSPs) differing in processing capacity. Samples of bioaerosol for inhalable dust (gravimetric method), endotoxins (LAL test in kinetic, chromogenic version) and (1–3)-b-D-glucans (Glucatell test in kinetic version) were collected from 42 sorting workers using individual aspirators with glass fiber filters during the work shift. Average geometric concentrations (geometric standard deviation; min–max) of inhalable dust, endotoxins and (1–3)-b-D-glucans were: WSP1: 1.7 mg m-3 (2.2; 0.6–6.9 mg m-3); 15.9 ng m-3 (2.1; 5.4–78.9 ng m-3), 55.1 ng m-3 (1.8; 20.7–188.6 ng m-3) and WSP2: 0.8 mg m-3 (2.2; 0.2–3.8 mg m-3), 9.8 ng m-3 (2.4; 1.6–29.7 ng m-3), 45.0 ng m-3 (3.2, 5.7–212.9 ng m-3), espectively. A significantly higher concentration of inhalable dust was recorded in WSP1 with bigger processing capacity compared to WSP2 (less processing capacity). Significant (p\0.05) and very high correlations (Spearman rank R[0.7) were found between the concentrations of all analyzed harmful agents. Processing capacity of waste sorting plants differentially affects the concentrations of inhalable dust, whereas concentrations of endotoxins and glucans are less clearly affected. This suggests that relative concentrations of endotoxin and glucan are depending on the waste sorting capacity.
    • Inter-laboratory comparison of nanoparticle size measurements using dynamic light scattering and differential centrifugal sedimentation

      Langevin, D.; Lozano, O.; Salvati, A.; Kestens, V.; Monopoli, M.; Raspaud, E.; Mariot, S.; Salonen, A.; Thomas, S.; Driessen, M.; et al. (2018-04)
      Nanoparticle in vitro toxicity studies often report contradictory results with one main reason being insufficient material characterization. In particular the characterization of nanoparticles in biological media remains challenging. Our aim was to provide robust protocols for two of the most commonly applied techniques for particle sizing, i.e. dynamic light scattering (DLS) and differential centrifugal sedimentation (DCS) that should be readily applicable also for users not specialized in nanoparticle physico-chemical characterization. A large number of participants (40, although not all participated in all rounds) were recruited for a series of inter-laboratory comparison (ILC) studies covering many different instrument types, commercial and custom-built, as another possible source of variation. ILCs were organized in a consecutive manner starting with dispersions in water employing well-characterized near-spherical silica nanoparticles (nominal 19 nm and 100 nm diameter) and two types of functionalized spherical polystyrene nanoparticles (nominal 50 nm diameter). At first each laboratory used their in-house established procedures. In particular for the 19 nm silica particles, the reproducibility of the methods was unacceptably high (reported results were between 10 nm and 50 nm). When comparing the results of the first ILC round it was observed that the DCS methods performed significantly worse than the DLS methods, thus emphasizing the need for standard operating procedures (SOPs). SOPs have been developed by four expert laboratories but were tested for robustness by a larger number of independent users in a second ILC (11 for DLS and 4 for DCS). In a similar approach another SOP for complex biological fluids, i.e. cell culture medium containing serum was developed, again confirmed via an ILC with 8 participating laboratories. Our study confirms that well-established and fit-for-purpose SOPs are indispensable for obtaining reliable and comparable particle size data. Our results also show that these SOPs must be optimized with respect to the intended measurement system (e.g. particle size technique, type of dispersant) and that they must be sufficiently detailed (e.g. avoiding ambiguity regarding measurand definition, etc.). SOPs may be developed by a small number of expert laboratories but for their widespread applicability they need to be verified by a larger number of laboratories.
    • Is eye lens dosimetry needed in nuclear medicine?

      Wrzesień, M; Królicki, L; Albiniak, Ł; Olszewski, J; Nofer Institute of Occupational Medicine (2018-06)
      The exact level of exposure experienced by nuclear medicine personnel, whose work often requires performing manual procedures involving radioactive isotopes, is associated with the form of radiation source used. The variety of radionuclides and medical procedures, and the yearly increase in the number of patients, as well as the change of the individual dose limit for the lens of the eye from a value of 150 mSv yr-1 to 20 mSv yr-1, mean that issues of eye lens routine dosimetry become interesting from the radiation protection point of view.
    • Is it possible to improve compliance in hypertension and reduce therapeutic inertia of physicians by mandatory periodical examinations of workers?

      Marcinkiewicz, Andrzej; Plewka, Michał; Hanke, Wojciech; Kałużny, Paweł; Wiszniewska, Marta; Lipińska-Ojrzanowska, Agnieszka; Walusiak-Skorupa, Jolanta; Nofer Institute of Occupational Medicine, Lodz, Poland (2018-01-19)
      Due to high prevalence, insufficient recognition and ineffectual treatment, hypertension (HT) still remains a major medical and socio-economic problem. There is a real necessity to develop effective prophylaxis for cardiovascular disorders (CVD), based on strategies which support compliance during long-term therapy. The Polish scheme of occupational health services (OHS) with mandatory periodical employee check-ups creates a unique opportunity for effective HT prophylaxis. As a result visiting a doctor is required not only due to health ailments but also by law, which is especially important for those feeling well. It enables an improvement in tertiary prevention, including actions taken not only by the doctors of the OHS, but also by the physicians in charge of treating the patients.
    • Is ulnar nerve entrapment at wrist frequent among patients with carpal tunnel syndrome occupationally exposed to monotype wrist movements?

      Lewańska, Magdalena; Walusiak-Skorupa, Jolanta; Nofer Institute of Occupational Medicine, Łódź, Poland (2017-10-06)
      Association between carpal tunnel syndrome (CTS) and ulnar nerve entrapment at wrist remains controversial. The aim of the study has been to investigate the prevalence of Guyon's canal syndrome amongst patients diagnosed with the CTS, occupationally exposed to repetitive wrist movements.
    • Isoprostanes - A novel major group of oxidative stress markers.

      Czerska, Marta; Zielinski, Marek; Gromadzinska, Jolanta; Nofer Institute of Occupational Medicine, Lodz, Poland (2015-12-17)
      Isoprostanes are a recently discovered group of prostaglandin isomers. Results of previous studies suggest that they can be used as oxidative stress markers, because in a number of cardiovascular, pulmonary and neurological diseases their levels in biological samples considerably increase. It has been found that people suffering from diabetes, obesity, homozygous familial hypercholesterolemia, moderate hypercholesterolemia, and smokers have higher levels of isoprostanes in urine. The same refers to patients with asthma, Alzheimer disease and Down syndrome. This paper reviews the results of relevant studies.
    • Jak firma może pomóc pracownikom w zdrowym odżywianiu i utrzymaniu prawidłowej masy ciała

      Instytut Medycyny Pracy. Krajowe Centrum Promocji Zdrowia w Miejscu Pracy.; Nofer Institute of Occupational Medicine, Łódź, Poland (2017)
      Niewłaściwe odżywianie się jest czynnikiem ryzyka wielu chorób, m.in. układu krążenia i nowotworów. Sprzyja też otyłości, którą Światowa Organizacja Zdrowia uznała za oddzielną chorobę, a w rozwiniętych społeczeństwach ważną przyczynę innych schorzeń i umieralności. Z drugiej strony wśród wielu przyczyn nadwagi i otyłości nie sposób pominąć sfery aktywności zawodowej. Współczesny człowiek coraz dłużej pracuje (więc może nie mieć czasu na racjonalny styl żywienia), często w nadmiernym stresie (z którym na ogół radzi sobie podjadając), w pozycji siedzącej i wydatkując coraz mniej energii. Stąd pomoc personelowi w zdrowym stylu odżywiania i zachowaniu optymalnej masy ciała staje się wyzwaniem dla firm, w kontekście coraz trudniejszego dla nich rynku. Broszura prezentuje przykładowe działania, które warto rozważyć planując taki zakładowy program.
    • Jak polscy pracownicy reaguja na informacje dotyczace prozdrowotnego stylu zycia?

      Korzeniowska, Elzbieta; Puchalski, Krzysztof; Nofer Institute of Occupational Medicine, Łódź, Poland (2017-06-27)
      Information overload, including commercial ones, about healthy lifestyle, is a challenge for perception of health education.
    • Jak zaklad pracy może zadbać o kondycję fizyczną personelu?

      Instytut Medycyny Pracy. Krajowe Centrum Promocji Zdrowia w Miejscu Pracy.; Nofer Institute of Occupational Medicine, Łódź, Poland (2017)
      Ludzki organizm jest przystosowany do ruchu, zwiększa on jego wydolność. Tymczasem postęp technologiczny powoduje, że społeczeństwo staje się mniej aktywne fizycznie, również w trakcie wykonywania obowiązków służbowych, kiedy pracujący coraz częściej po prostu siedzą. Co więcej, znużenie czy dolegliwości bólowe (np. ze strony układu ruchu) będące skutkiem pracy w wymuszonej pozycji, osłabiają potrzebę i możliwości podejmowania rekreacyjnej aktywności fizycznej. I w ten sposób koło się zamyka – współczesny styl pracy nie sprzyja zachowywaniu sprawności i m.in. w jego efekcie brakuje chęci/motywacji, by w czasie wolnym zrobić coś dla utrzymania czy poprawy własnej kondycji fizycznej. Dlatego pracodawcy decydują się popularyzować ćwiczenia i wysiłek fizyczny wśród swojego personelu.