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dc.contributor.authorBoateng, J.
dc.contributor.authorVerghese, M.
dc.contributor.authorChawan, C.B.
dc.contributor.authorShackelford, L.
dc.contributor.authorWalker, L.T.
dc.contributor.authorKhatiwada, J.
dc.contributor.authorWilliams, D.S.
dc.date.accessioned2009-03-16T09:11:13Z
dc.date.available2009-03-16T09:11:13Z
dc.date.issued2006-10
dc.identifier.citationFood Chem. Toxicol. 2006, 44 (10):1667-1673en
dc.identifier.issn0278-6915
dc.identifier.pmid16822603
dc.identifier.doi10.1016/j.fct.2006.05.002
dc.identifier.urihttp://hdl.handle.net/10146/55553
dc.descriptionDietary modulation of cancer & cancer biomarkersDietary item or component studied: Red palm oil (RPO)Outcome studied: aberrant crypt foci (ACF)Study type: male Fisher 344 rats Tissue/biological material/sample size: colonMode of exposure: dietaryImpact on outcome (including dose-response): Numbers of ACF (mean+/-SE) in the proximal and distal colon were: 39.9 +/- 0.9, 53.8 +/- 2.8, 26.0 +/- 3.0, 27.5 +/- 1.5 and 118.2 +/- 1.7, 125.6 +/- 3.2, 41 +/- 7, 52.3 +/- 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively. KEYWORDS - CLASSIFICATION: Animals;Azoxymethane;Carotenoids;chemically induced;Colonic Neoplasms;dietary modulation of cancer & cancer biomarkers;drug effects;Eating;enzymology;Food;Glutathione;Glutathione Transferase;humans;Liver;Male;metabolism;Oils;pharmacology;Plant Oils;Precancerous Conditions;prevention & control;Rats;Rats,Inbred F344;Soybean Oil;Vitamin E;Weight Gain;en
dc.description.abstractRed palm oil (RPO) contains significant levels of carotenoids and Vitamin E. In this experiment we compared the inhibitory effects of RPO (7% and 14% levels) and soybean oil (7% and 14%) on azoxymethane (AOM) induced aberrant crypt foci (ACF). Thirty-two male Fisher 344 rats were randomly assigned to four groups. Two groups received AIN-93 G control (C) diet containing 7% and 14% soybean oil (SBO), respectively. Groups 3 and 4 received a treatment diet consisting of 7% and 14% RPO, respectively. The rats received subcutaneous injections of AOM at 16 mg/kg body weight at 7 and 8 weeks of age. At 17 weeks of age rats were killed by CO(2) asphyxiation. Numbers of ACF (mean+/-SE) in the proximal and distal colon were: 39.9 +/- 0.9, 53.8 +/- 2.8, 26.0 +/- 3.0, 27.5 +/- 1.5 and 118.2 +/- 1.7, 125.6 +/- 3.2, 41 +/- 7, 52.3 +/- 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively. The results of this study showed that RPO reduced the incidence of AOM induced ACF and may therefore have a beneficial effect in reducing the incidence of colon cancer.
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6P-4K0029H-1&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=6b7bfedd20e25490e80bd99e96f183dcen
dc.subjectRed palm oilen
dc.subjectAzoxymethaneen
dc.subjectAberrant crypt focien
dc.subjectCarotenoidsen
dc.subjectVitamin Een
dc.subject.meshAnimals
dc.subject.meshAzoxymethane
dc.subject.meshCarotenoids
dc.subject.meshColonic Neoplasms
dc.subject.meshEating
dc.subject.meshGlutathione Transferase
dc.subject.meshLiver
dc.subject.meshMale
dc.subject.meshPlant Oils
dc.subject.meshPrecancerous Conditions
dc.subject.meshRats
dc.subject.meshRats, Inbred F344
dc.subject.meshSoybean Oil
dc.subject.meshVitamin E
dc.subject.meshWeight Gain
dc.titleRed palm oil suppresses the formation of azoxymethane (AOM) induced aberrant crypt foci (ACF) in Fisher 344 male rats.en
dc.typeArticleen
dc.identifier.journalFood and Chemical Toxicology : an international journal published for the British Industrial Biological Research Associationen
html.description.abstractRed palm oil (RPO) contains significant levels of carotenoids and Vitamin E. In this experiment we compared the inhibitory effects of RPO (7% and 14% levels) and soybean oil (7% and 14%) on azoxymethane (AOM) induced aberrant crypt foci (ACF). Thirty-two male Fisher 344 rats were randomly assigned to four groups. Two groups received AIN-93 G control (C) diet containing 7% and 14% soybean oil (SBO), respectively. Groups 3 and 4 received a treatment diet consisting of 7% and 14% RPO, respectively. The rats received subcutaneous injections of AOM at 16 mg/kg body weight at 7 and 8 weeks of age. At 17 weeks of age rats were killed by CO(2) asphyxiation. Numbers of ACF (mean+/-SE) in the proximal and distal colon were: 39.9 +/- 0.9, 53.8 +/- 2.8, 26.0 +/- 3.0, 27.5 +/- 1.5 and 118.2 +/- 1.7, 125.6 +/- 3.2, 41 +/- 7, 52.3 +/- 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively. The results of this study showed that RPO reduced the incidence of AOM induced ACF and may therefore have a beneficial effect in reducing the incidence of colon cancer.


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