Red palm oil suppresses the formation of azoxymethane (AOM) induced aberrant crypt foci (ACF) in Fisher 344 male rats.
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AbstractRed palm oil (RPO) contains significant levels of carotenoids and Vitamin E. In this experiment we compared the inhibitory effects of RPO (7% and 14% levels) and soybean oil (7% and 14%) on azoxymethane (AOM) induced aberrant crypt foci (ACF). Thirty-two male Fisher 344 rats were randomly assigned to four groups. Two groups received AIN-93 G control (C) diet containing 7% and 14% soybean oil (SBO), respectively. Groups 3 and 4 received a treatment diet consisting of 7% and 14% RPO, respectively. The rats received subcutaneous injections of AOM at 16 mg/kg body weight at 7 and 8 weeks of age. At 17 weeks of age rats were killed by CO(2) asphyxiation. Numbers of ACF (mean+/-SE) in the proximal and distal colon were: 39.9 +/- 0.9, 53.8 +/- 2.8, 26.0 +/- 3.0, 27.5 +/- 1.5 and 118.2 +/- 1.7, 125.6 +/- 3.2, 41 +/- 7, 52.3 +/- 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively. The results of this study showed that RPO reduced the incidence of AOM induced ACF and may therefore have a beneficial effect in reducing the incidence of colon cancer.
CitationFood Chem. Toxicol. 2006, 44 (10):1667-1673
JournalFood and Chemical Toxicology : an international journal published for the British Industrial Biological Research Association
DescriptionDietary modulation of cancer & cancer biomarkersDietary item or component studied: Red palm oil (RPO)Outcome studied: aberrant crypt foci (ACF)Study type: male Fisher 344 rats Tissue/biological material/sample size: colonMode of exposure: dietaryImpact on outcome (including dose-response): Numbers of ACF (mean+/-SE) in the proximal and distal colon were: 39.9 +/- 0.9, 53.8 +/- 2.8, 26.0 +/- 3.0, 27.5 +/- 1.5 and 118.2 +/- 1.7, 125.6 +/- 3.2, 41 +/- 7, 52.3 +/- 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively. KEYWORDS - CLASSIFICATION: Animals;Azoxymethane;Carotenoids;chemically induced;Colonic Neoplasms;dietary modulation of cancer & cancer biomarkers;drug effects;Eating;enzymology;Food;Glutathione;Glutathione Transferase;humans;Liver;Male;metabolism;Oils;pharmacology;Plant Oils;Precancerous Conditions;prevention & control;Rats;Rats,Inbred F344;Soybean Oil;Vitamin E;Weight Gain;
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