Red palm oil suppresses the formation of azoxymethane (AOM) induced aberrant crypt foci (ACF) in Fisher 344 male rats.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractRed palm oil (RPO) contains significant levels of carotenoids and Vitamin E. In this experiment we compared the inhibitory effects of RPO (7% and 14% levels) and soybean oil (7% and 14%) on azoxymethane (AOM) induced aberrant crypt foci (ACF). Thirty-two male Fisher 344 rats were randomly assigned to four groups. Two groups received AIN-93 G control (C) diet containing 7% and 14% soybean oil (SBO), respectively. Groups 3 and 4 received a treatment diet consisting of 7% and 14% RPO, respectively. The rats received subcutaneous injections of AOM at 16 mg/kg body weight at 7 and 8 weeks of age. At 17 weeks of age rats were killed by CO(2) asphyxiation. Numbers of ACF (mean+/-SE) in the proximal and distal colon were: 39.9 +/- 0.9, 53.8 +/- 2.8, 26.0 +/- 3.0, 27.5 +/- 1.5 and 118.2 +/- 1.7, 125.6 +/- 3.2, 41 +/- 7, 52.3 +/- 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively. The results of this study showed that RPO reduced the incidence of AOM induced ACF and may therefore have a beneficial effect in reducing the incidence of colon cancer.
CitationFood Chem. Toxicol. 2006, 44 (10):1667-1673
JournalFood and Chemical Toxicology : an international journal published for the British Industrial Biological Research Association
DescriptionDietary modulation of cancer & cancer biomarkersDietary item or component studied: Red palm oil (RPO)Outcome studied: aberrant crypt foci (ACF)Study type: male Fisher 344 rats Tissue/biological material/sample size: colonMode of exposure: dietaryImpact on outcome (including dose-response): Numbers of ACF (mean+/-SE) in the proximal and distal colon were: 39.9 +/- 0.9, 53.8 +/- 2.8, 26.0 +/- 3.0, 27.5 +/- 1.5 and 118.2 +/- 1.7, 125.6 +/- 3.2, 41 +/- 7, 52.3 +/- 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively. KEYWORDS - CLASSIFICATION: Animals;Azoxymethane;Carotenoids;chemically induced;Colonic Neoplasms;dietary modulation of cancer & cancer biomarkers;drug effects;Eating;enzymology;Food;Glutathione;Glutathione Transferase;humans;Liver;Male;metabolism;Oils;pharmacology;Plant Oils;Precancerous Conditions;prevention & control;Rats;Rats,Inbred F344;Soybean Oil;Vitamin E;Weight Gain;
- Flax seed oil and flax seed meal reduce the formation of aberrant crypt foci (ACF) in azoxymethane-induced colon cancer in Fisher 344 male rats.
- Authors: Williams D, Verghese M, Walker LT, Boateng J, Shackelford L, Chawan CB
- Issue date: 2007 Jan
- Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats.
- Authors: Boateng J, Verghese M, Shackelford L, Walker LT, Khatiwada J, Ogutu S, Williams DS, Jones J, Guyton M, Asiamah D, Henderson F, Grant L, DeBruce M, Johnson A, Washington S, Chawan CB
- Issue date: 2007 May
- Dietary inulin suppresses azoxymethane-induced preneoplastic aberrant crypt foci in mature Fisher 344 rats.
- Authors: Verghese M, Rao DR, Chawan CB, Shackelford L
- Issue date: 2002 Sep
- Catalpa seed oil rich in 9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats.
- Authors: Suzuki R, Yasui Y, Kohno H, Miyamoto S, Hosokawa M, Miyashita K, Tanaka T
- Issue date: 2006 Nov
- Modifying effect of tuna orbital oil rich in docosahexaenoic acid and vitamin D3 on azoxymethane-induced colonic aberrant crypt foci in rats.
- Authors: Kohno H, Yamaguchi N, Ohdoi C, Nakajima S, Odashima S, Tanaka T
- Issue date: 2000 Sep-Oct