Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Satia, Jessie A.
Kupper, Lawrence L.
Millikan, Robert C.
Sandler, Robert S.
MetadataShow full item record
AbstractBACKGROUND: Selenium is an essential trace element found in cereals, wheat, dairy products, meat, and fish. This micronutrient may prevent carcinogenesis through several biochemical pathways; one suggested pathway is enhanced apoptosis. OBJECTIVES: The relation between selenium and colorectal adenomas was evaluated because the colorectal adenoma is the established precursor lesion of most colorectal cancers. Apoptosis was a pathway of interest because decreased apoptosis has been associated with an increased prevalence of adenomas. Our objectives were as follows: to investigate the association between (a) selenium and colorectal adenomas and (b) selenium and apoptosis. METHODS: The study population was assembled for the Diet and Health Study III (n = 803), a cross-sectional study conducted at the University of North Carolina Hospital (Chapel Hill, NC). There were 451 participants in the analysis of selenium and adenoma prevalence and 351 participants in the analysis of selenium and apoptosis. Selenium was measured from serum collected at the time of colonoscopy. Apoptosis was measured in biopsies from normal rectal epithelium obtained during the colonoscopy procedure. RESULTS: Participants in the highest fifth of serum selenium were less likely to have adenomas in comparison with those in the lowest fifth (prevalence ratio, 0.6; 95% confidence interval, 0.4-1.1). Selenium and apoptosis (>2.76 cells per crypt) were not strongly related, but results collectively suggested a roughly inverse association. CONCLUSIONS: High selenium was associated with a reduced prevalence of colorectal adenomas. Apoptosis, however, did not seem to be the mechanism by which selenium was related to adenoma prevalence in our data.
CitationCancer Epidemiol. Biomarkers Prev. 2006, 15 (3):486-93
DescriptionDietary modulation of carcinogenesis-related pathwaysDietary item or component studied:seleniumPathways studied:apoptosisStudy type (in vitro, animals, humans): humansStudy design (if human):cross-sectional studyStudy size (if human):803 participantsTissue/biological material/sample size: serum, 2 colon biopsiesMode of exposure (if in vivo) (acute, chronic, root of exposure):dietary & lifestyle questionnairesImpact on pathway (including dose-response):for 50-120 μgr/l selenium Pe~0.5-0.3For selenium 120-160 μgr/l Pe~0.4for selenium<160μgr/l Pe~0.3-0.1high selinium intake(>140μgr/l) associated with decreased prevalence of high apoptosis compared to low selenium levels(<140μgr/l)Notes:inverse association between selenium intake and apoptosisDietary modulation of cancer & cancer biomarkers Dietary item or component studied:seleniumOutcome studied (cancer or cancer biomarker):adenocarcinomasStudy type (in vitro, animals, humans): humansStudy design (if human):cross-sectional studyStudy size (if human):803 participantsTissue/biological material/sample size:serum, 2 colon biopsiesMode of exposure (if in vivo):dietary & lifestyle questionnaires. KEYWORDS CLASSIFICATION: analysis;Adenoma;Adult;Age Distribution;Aged;Aged,80 and over;Apoptosis;blood;Biopsy,Needle;cancer epidemiology;Colorectal Neoplasms;Cross-Sectional Studies;Diet;dietary modulation of cancer & cancer biomarkers;dietary modulation of carcinogenesis-related pathways;epidemiology;Female;Humans;Immunohistochemistry;Linear Models;Male;Middle Aged;Neoplasm Staging;North Carolina;pathology;physiology;Prevalence;Probability;Prognosis;Reference Values;Research;Risk Assessment;Selenium;Sensitivity and Specificity;Sex Distribution;Tumor Markers,Biological.
- Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps.
- Authors: Schoen RE, Weissfeld JL, Kuller LH, Thaete FL, Evans RW, Hayes RB, Rosen CJ
- Issue date: 2005 Aug
- Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps.
- Authors: Clark LC, Hixson LJ, Combs GF Jr, Reid ME, Turnbull BW, Sampliner RE
- Issue date: 1993 Jan-Feb
- Insulin resistance, apoptosis, and colorectal adenoma risk.
- Authors: Keku TO, Lund PK, Galanko J, Simmons JG, Woosley JT, Sandler RS
- Issue date: 2005 Sep
- Selenium and colorectal adenoma: results of a pooled analysis.
- Authors: Jacobs ET, Jiang R, Alberts DS, Greenberg ER, Gunter EW, Karagas MR, Lanza E, Ratnasinghe L, Reid ME, Schatzkin A, Smith-Warner SA, Wallace K, Martínez ME
- Issue date: 2004 Nov 17
- Decreased high-density lipoprotein cholesterol and increased low-density cholesterol levels in patients with colorectal adenomas.
- Authors: Bayerdörffer E, Mannes GA, Richter WO, Ochsenkühn T, Seeholzer G, Köpcke W, Wiebecke B, Paumgartner G
- Issue date: 1993 Apr 1