Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Neschen, SusanneMorino, Katsutaro
Rossbacher, Jörg C.
Pongratz, Rebecca L.
Cline, Gary W.
Sono, Saki
Gillum, Matthew
Shulman, Gerald I.
Issue Date
2006-04
Metadata
Show full item recordAbstract
Adiponectin has insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, but little is known about factors that regulate its secretion. To examine the effect of fish oil on adiponectin secretion, mice were fed either a control diet or isocaloric diets containing 27% safflower oil or 27, 13.5, and 8% menhaden fish oil. Within 15 days, fish oil feeding raised plasma adiponectin concentrations two- to threefold in a dose-dependent manner, and the concentrations remained approximately twofold higher for 7 days when the fish oil diet was replaced by the safflower oil diet. Within 24 h, fish oil markedly induced transcription of the adiponectin gene in epididymal adipose tissue but not in subcutaneous fat. The increase of plasma adiponectin by fish oil was completely blocked by administration of the peroxisome proliferator-activated receptor (PPAR)gamma inhibitor bisphenol-A-diglycidyl ether. In contrast, there was no effect of fish oil feeding on adiponectin secretion in PPARalpha-null mice. These data suggest that fish oil is a naturally occurring potent regulator of adiponectin secretion in vivo and that it does so through a PPARgamma-dependent and PPARalpha-independent manner in epididymal fat.Citation
Diabetes 2006, 55 (4):924-928Journal
DiabetesPubMed ID
16567512Additional Links
http://diabetes.diabetesjournals.org/cgi/content/full/55/4/924Type
ArticleLanguage
enDescription
Dietary modulation of carcinogenesis-related pathwaysDietary item or component studied: fish oilPathways studied: adiponectin gene expressionStudy type (in vitro, animals, humans): 129Sv miceTissue/biological material/sample size: total plasmaMode of exposure (if in vivo) (acute, chronic, root of exposure): chronic (15 days) and acute dietImpact on pathway (including dose-response): 31+-2.8, n=4 vs 25.6+-3.5, n=4μgr/ml plasma adiponectin in 14.5%fish oil-fed mice. KEYWORDS CLASSIFICATION: Adiponectin;Adipose Tissue;Animals;Antigens,CD36;blood;deficiency;dietary modulation of carcinogenesis-related pathways;drug effects;DNA Primers;Epididymis;Epoxy Compounds;Fish Oils;genetics;Gene Expression Regulation;Male;Mice;Mice,Inbred Strains;Mice,Knockout;Oils;pharmacology;physiology;PPAR gamma;Research;Reverse Transcriptase Polymerase Chain Reaction;secretion;Transcription,Genetic;ISSN
0012-1797ae974a485f413a2113503eed53cd6c53
10.2337/diabetes.55.04.06.db05-0985
Scopus Count
Collections
Related articles
- n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.
- Authors: Neschen S, Morino K, Dong J, Wang-Fischer Y, Cline GW, Romanelli AJ, Rossbacher JC, Moore IK, Regittnig W, Munoz DS, Kim JH, Shulman GI
- Issue date: 2007 Apr
- Docosahexaenoic acid increases cellular adiponectin mRNA and secreted adiponectin protein, as well as PPARγ mRNA, in 3T3-L1 adipocytes.
- Authors: Oster RT, Tishinsky JM, Yuan Z, Robinson LE
- Issue date: 2010 Dec
- Dietary fish oil did not prevent sleep deprived rats from a reduction in adipose tissue adiponectin gene expression.
- Authors: de Mattos AB, Pinto MJ, Oliveira C, Biz C, Ribeiro EB, do Nascimento CM, Andersen ML, Tufik S, Oyama LM
- Issue date: 2008 Nov 5
- Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism.
- Authors: Landrier JF, Gouranton E, El Yazidi C, Malezet C, Balaguer P, Borel P, Amiot MJ
- Issue date: 2009 Dec