Urinary 1-hydroxypyrene as a biomarker of PAH exposure in 3-year-old Ukrainian children.
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AuthorsMucha, Amy Pelka
MetadataShow full item record
AbstractUrinary 1-hydroxypyrene (1-OHP) is a biomarker of polycyclic aromatic hydrocarbon (PAH) exposure. We measured urinary 1-OHP in 48 children 3 years of age in Mariupol, Ukraine, who lived near a steel mill and coking facility and compared these with 1-OHP concentrations measured in 42 children of the same age living in the capital city of Kiev, Ukraine. Children living in Mariupol had significantly higher urinary 1-OHP and creatinine-adjusted urinary 1-OHP than did children living in Kiev (adjusted: 0.69 vs. 0.34 micromol/mol creatinine, p < 0.001; unadjusted: 0.42 vs. 0.30 ng/mL, p = 0.002). Combined, children in both cities exposed to environmental tobacco smoke in their homes had higher 1-OHP than did children not exposed (0.61 vs. 0.42 micromol/mol creatinine; p = 0.04; p = 0.07 after adjusting for city). In addition, no significant differences were seen with sex of the children. Our sample of children in Mariupol has the highest reported mean urinary 1-OHP concentrations in children studied to date, most likely due to their proximity to a large industrial point source of PAHs.
CitationEnviron. Health Perspect. 2006, 114 (4):603-609
DescriptionBiomarkers of exposure & early effects: field studiesBiomarker: 1-hydroxypyrene (1-OHP)Exposure/effect represented: PAHStudy design: cross-sectionalStudy size: 48 children from Mariupol and 42 children from KievAnalytical technique: reverse-phase high-performance liquid chromatography with enzymatic hydrolysis using β- glucuronidase/arylsulfataseTissue/biological material/sample size: urineHalf-life of biomarker: 9.8 hrSurrogate/target tissue relationship: goodRelationship with exposure or effect of interest (including dose-response): 0.69ngr/ml in Mariupol vs 0.34ngr/ml in Kiev, p= 0.0001Factors modulating biomarkers: ETS Keywords classification: analysis;biomarkers of exposure & effect: field studies;Biological Markers;Child,Preschool;Environmental Exposure;Epidemiologic Studies;Female;Humans;Male;Polycyclic Compounds;Public Health;Pyrenes;Research;Safety;urine;Ukraine;
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