Effects of soybean glyceollins and estradiol in postmenopausal female monkeys.
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AuthorsWood, Charles E.
Clarkson, Thomas B.
Appt, Susan E.
Franke, Adrian A.
Boue, Stephen M.
Burow, Matthew E.
Cline, J. Mark
MetadataShow full item record
AbstractGlyceollins are a novel class of soybean phytoalexins with potential cancer-protective antiestrogenic effects. The purpose of this study was to evaluate the estrogen-antagonist effects of glyceollin-enriched soy protein on biomarkers for breast cancer risk. Thirty female postmenopausal cynomolgus macaques were randomized to one of three dietary treatments for 3 wk: 1) estradiol (E2, 1 mg/day) + casein/lactalbumin (control); 2) E2 + soy protein isolate (SPI) containing 194 mg/day isoflavonoids; and 3) E2 + glyceollin-enriched soy protein (GLY) containing 189 mg/day isoflavonoids + 134 mg/day glyceollins. Doses are expressed in calorically scaled human equivalents. Mean serum glyceollin concentrations at 4 h postfeeding were 134.2 +/- 34.6 nmol/L in the GLY group and negligible in the SPI group (P = 0.0007). Breast proliferation was significantly increased in the control group (+237%, P = 0.01) but not in the SPI group (+198%, P = 0.08) or GLY group (+36%, P = 0.18). Gene expression of trefoil factor 1 and progesterone receptor, two markers of estrogen receptor activity in breast epithelium, were also significantly higher in the control (P < 0.05 for both) but not in the GLY group. These preliminary findings suggest that soybean glyceollins are natural compounds with potential estrogen-modulating properties in the breast.
CitationNutr. Cancer 2006, 56 (1):74-81.
JournalNutrition and cancer
DescriptionDietary modulation of cancer & cancer biomarkers; Dietary modulation of carcinogenesis-related pathwaysDietary item or component studied: glyceollinsOutcome studied: Breast proliferation; gene expression of trefoil factor 1; gene expression of progesterone receptorStudy type: cynomolgus macaquesTissue/biological material/sample size: Breast tissueMode of exposure: dietaryImpact on outcome (including dose-response): Breast proliferation was significantly increased in the control group (+237%, P = 0.01) but not in the SPI group (+198%, P = 0.08) or GLY group (+36%, P = 0.18). Gene expression of trefoil factor 1 and progesterone receptor, two markers of estrogen receptor activity in breast epithelium, were also significantly higher in the control (P < 0.05 for both) but not in the GLY group.
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