Occupational exposures, environmental tobacco smoke, and lung cancer.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Gonzalez, Carlos A.
Quiros, J. Ramon
Day, Nicholas E.
MetadataShow full item record
AbstractBACKGROUND: There is uncertainty regarding the association of occupational exposures with lung cancer. We have studied the association between 52 high-risk job titles and lung cancer incidence in a large prospective study, with more than 200,000 participants followed for more than 6 years and 809 incident cases of lung cancer. METHODS: Hazard ratios and 95% confidence intervals were computed by the Cox proportional-hazard regression model, adjusting for country, age, sex, social class, diet, physical activity, and smoking habits. We used a CAREX-based job-exposure matrix to infer exposure to lung carcinogens. False-positive report probability was calculated as a measure of potentially false-positive results. RESULTS: Eighteen occupations, mainly related with agriculture, constructions, and metal processing, were associated with increased risk. In addition, incidence tended to increase with the number of hazardous jobs reported. When the occupations were classified according to the presumed exposure to specific carcinogenic agents, the hazard ratios were 1.5 (95% confidence interval = 1.2-1.9) for asbestos, 1.4 (1.1-1.8) for heavy metals, 1.4 (1.1-1.8) for polycyclic aromatic hydrocarbons, and 1.6 (1.2-2.1) for work-related environmental tobacco smoke. The estimated population attributable risk for employment in at least 1 at-risk job was 16% in men and 12% in women. CONCLUSIONS: This large prospective study suggests that exposure to occupational lung carcinogens is still a problem, with such exposures producing moderate to large increases in risk.
CitationEpidemiology 2007, 18 (6):769-775
JournalEpidemiology (Cambridge, Mass.)
- Occupation and cancer - follow-up of 15 million people in five Nordic countries.
- Authors: Pukkala E, Martinsen JI, Lynge E, Gunnarsdottir HK, Sparén P, Tryggvadottir L, Weiderpass E, Kjaerheim K
- Issue date: 2009
- Occupational exposure to carcinogens and risk of lung cancer: results from The Netherlands cohort study.
- Authors: van Loon AJ, Kant IJ, Swaen GM, Goldbohm RA, Kremer AM, van den Brandt PA
- Issue date: 1997 Nov
- A case-control study of lung cancer and environmental tobacco smoke among nonsmoking women living in Shanghai, China.
- Authors: Zhong L, Goldberg MS, Gao YT, Jin F
- Issue date: 1999 Dec
- Occupational risk of lung cancer among lifetime non-smoking women in Shanghai, China.
- Authors: Pronk A, Coble J, Ji BT, Shu XO, Rothman N, Yang G, Gao YT, Zheng W, Chow WH
- Issue date: 2009 Oct
- Impact of occupational carcinogens on lung cancer risk in a general population.
- Authors: De Matteis S, Consonni D, Lubin JH, Tucker M, Peters S, Vermeulen RCh, Kromhout H, Bertazzi PA, Caporaso NE, Pesatori AC, Wacholder S, Landi MT
- Issue date: 2012 Jun