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dc.contributor.authorMendez, Michelle A.
dc.contributor.authorPera, Guillem
dc.contributor.authorAgudo, Antonio
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorPalli, Domenico
dc.contributor.authorBoeing, Heiner
dc.contributor.authorCarneiro, Fatima
dc.contributor.authorBerrino, Franco
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorTumino, Rosario
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBerglund, Goran
dc.contributor.authorManjer, Jonas
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorStenling, Roger
dc.contributor.authorMartinez, Carmen
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorTormo, Maria J.
dc.contributor.authorQuiros, Jose R.
dc.contributor.authorAllen, Naomi
dc.contributor.authorKey, Timothy J.
dc.contributor.authorBingham, Sheila
dc.contributor.authorLinseisen, Jakob
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorOvervad, Kim
dc.contributor.authorJensen, Majken
dc.contributor.authorOlsen, Anja
dc.contributor.authorTjonneland, Anne
dc.contributor.authorPeeters, Petra H.M.
dc.contributor.authorNumans, Mattijs E.
dc.contributor.authorOcke, Marga C.
dc.contributor.authorClavel-Chapelon, Francoise
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLund, Eiliv
dc.contributor.authorSlimani, Nadia
dc.contributor.authorJenab, Mazda
dc.contributor.authorFerrari, Pietro
dc.contributor.authorRiboli, Elio
dc.contributor.authorGonzalez, Carlos A.
dc.date.accessioned2008-08-29T11:14:49Z
dc.date.available2008-08-29T11:14:49Z
dc.date.issued2007-10-01
dc.identifier.citationInt. J. Cancer 2007, 121 (7):1618-1623en
dc.identifier.issn0020-7136
dc.identifier.pmid17582605
dc.identifier.doi10.1002/ijc.22896
dc.identifier.urihttp://hdl.handle.net/10146/36852
dc.description.abstractNumerous case-control studies suggest dietary fiber may reduce risk of gastric cancer, but this has not been confirmed prospectively. A previous case-control study reported reduced risk of gastric cardia adenocarcinomas associated with cereal fiber, but not with fruit or vegetable fiber. To date, different food sources of fiber have not been examined with respect to noncardia tumors or diverse histologic sub-types. This study prospectively examines associations between fiber from different food sources and incident gastric adenocarcinomas (GC) among more than 435,000 subjects from 10 countries participating in the European Prospective Investigation into Cancer and Nutrition study. Subjects aged 25-70 years completed dietary questionnaires in 1992-98, and were followed up for a median of 6.7 years. About 312 incident GCs were observed. The relative risk of GC was estimated based on cohort-wide sex-specific fiber intake quartiles using proportional hazards models to estimate hazards ratios (HRs) and 95% confidence intervals (CIs). Intakes of cereal fiber, but not total, fruit or vegetable fiber, were associated with reduced GC risk [adjusted HR for the highest vs. lowest quartile of cereal fiber 0.69, 0.48-0.99]. There was a strong inverse association for diffuse [HR 0.43, 0.22-0.86], but not intestinal type [HR 0.98, 0.54-1.80] tumors. Associations for cardia vs. noncardia tumors were similar to those for overall GC, although cardia associations did not reach significance. Cereal fiber consumption may help to reduce risk of GC, particularly diffuse type tumors. Further study on different food sources of fiber in relation to GC risk is warranted to confirm these relationships.
dc.language.isoenen
dc.relation.urlhttp://www3.interscience.wiley.com/journal/114281151/abstracten
dc.subjectcereal fiberen
dc.subjectgastric canceren
dc.subjectcohort studyen
dc.subject.meshAdenocarcinoma
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCereals
dc.subject.meshData Collection
dc.subject.meshDietary Fiber
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshFruit
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshMiddle Aged
dc.subject.meshProportional Hazards Models
dc.subject.meshQuestionnaires
dc.subject.meshRisk Factors
dc.subject.meshStomach Neoplasms
dc.subject.meshVegetables
dc.titleCereal fiber intake may reduce risk of gastric adenocarcinomas: the EPIC-EURGAST study.en
dc.typeArticleen
dc.identifier.journalInternational Journal of Cancer. Journal international du canceren
html.description.abstractNumerous case-control studies suggest dietary fiber may reduce risk of gastric cancer, but this has not been confirmed prospectively. A previous case-control study reported reduced risk of gastric cardia adenocarcinomas associated with cereal fiber, but not with fruit or vegetable fiber. To date, different food sources of fiber have not been examined with respect to noncardia tumors or diverse histologic sub-types. This study prospectively examines associations between fiber from different food sources and incident gastric adenocarcinomas (GC) among more than 435,000 subjects from 10 countries participating in the European Prospective Investigation into Cancer and Nutrition study. Subjects aged 25-70 years completed dietary questionnaires in 1992-98, and were followed up for a median of 6.7 years. About 312 incident GCs were observed. The relative risk of GC was estimated based on cohort-wide sex-specific fiber intake quartiles using proportional hazards models to estimate hazards ratios (HRs) and 95% confidence intervals (CIs). Intakes of cereal fiber, but not total, fruit or vegetable fiber, were associated with reduced GC risk [adjusted HR for the highest vs. lowest quartile of cereal fiber 0.69, 0.48-0.99]. There was a strong inverse association for diffuse [HR 0.43, 0.22-0.86], but not intestinal type [HR 0.98, 0.54-1.80] tumors. Associations for cardia vs. noncardia tumors were similar to those for overall GC, although cardia associations did not reach significance. Cereal fiber consumption may help to reduce risk of GC, particularly diffuse type tumors. Further study on different food sources of fiber in relation to GC risk is warranted to confirm these relationships.


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