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    Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response.

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    Authors
    Herrlich, Peter
    Karin, Michael
    Weiss, Carsten
    Issue Date
    2008-02-15
    
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    Abstract
    Like their prokaryotic counterparts, mammalian cells can sense light, especially in the ultraviolet (UV) range of the spectrum. After UV exposure, cells mount an elaborate response--called the UV response--that mimics physiological signaling responses except that it targets multiple pathways, thereby lacking the defined specificity of receptor-triggered signal transduction. Despite many years of research, it is still not fully clear how UV radiation is sensed and converted into the "language of cells"--signal reception and transduction. This review focuses on how photonic energy and its primary cellular products are sensed to elicit the UV response.
    Citation
    Mol. Cell 2008, 29 (3):279-290
    Journal
    Molecular Cell
    URI
    http://hdl.handle.net/10146/36652
    DOI
    10.1016/j.molcel.2008.01.001
    PubMed ID
    18280234
    Additional Links
    http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSR-4RV20JP-1&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=1843694&md5=2d0de66af8651f7a3c67aa0f5f3baa49
    http://www.molecule.org/content/article/abstract?uid=PIIS1097276508000099
    Type
    Article
    Language
    en
    ISSN
    1097-2765
    Sponsors
    We are grateful to Dr. Z.Q. Wang for reading and discussing the manuscript and to F.-D. Boehmer for communicating unpublished data. C.W. is supported by the European Network of Excellence ECNIS. M.K. is an American Cancer Society Research Professor and work in his laboratory is supported by the National Institutes of Health. P.H. is supported by the Deutsche Forschungsgemeinschaft.
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.molcel.2008.01.001
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