Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response.
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Issue Date
2008-02-15
Metadata
Show full item recordAbstract
Like their prokaryotic counterparts, mammalian cells can sense light, especially in the ultraviolet (UV) range of the spectrum. After UV exposure, cells mount an elaborate response--called the UV response--that mimics physiological signaling responses except that it targets multiple pathways, thereby lacking the defined specificity of receptor-triggered signal transduction. Despite many years of research, it is still not fully clear how UV radiation is sensed and converted into the "language of cells"--signal reception and transduction. This review focuses on how photonic energy and its primary cellular products are sensed to elicit the UV response.Citation
Mol. Cell 2008, 29 (3):279-290Journal
Molecular CellPubMed ID
18280234Additional Links
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSR-4RV20JP-1&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=1843694&md5=2d0de66af8651f7a3c67aa0f5f3baa49http://www.molecule.org/content/article/abstract?uid=PIIS1097276508000099
Type
ArticleLanguage
enISSN
1097-2765Sponsors
We are grateful to Dr. Z.Q. Wang for reading and discussing the manuscript and to F.-D. Boehmer for communicating unpublished data. C.W. is supported by the European Network of Excellence ECNIS. M.K. is an American Cancer Society Research Professor and work in his laboratory is supported by the National Institutes of Health. P.H. is supported by the Deutsche Forschungsgemeinschaft.ae974a485f413a2113503eed53cd6c53
10.1016/j.molcel.2008.01.001
Scopus Count
Collections
Related articles
- Mechanisms of UV-induced signal transduction.
- Authors: Kulms D, Schwarz T
- Issue date: 2002 Apr
- The dark side of light: the damaging effects of UV rays and the protective efforts of MAP kinase signaling in the epidermis.
- Authors: Hildesheim J, Fornace AJ Jr
- Issue date: 2004 Jun 3
- The UV response of the skin: a review of the MAPK, NFkappaB and TNFalpha signal transduction pathways.
- Authors: Muthusamy V, Piva TJ
- Issue date: 2010 Jan
- Mitogen-activated protein kinase activation in UV-induced signal transduction.
- Authors: Bode AM, Dong Z
- Issue date: 2003 Jan 28
- How different wavelengths of the ultraviolet spectrum contribute to skin carcinogenesis: the role of cellular damage responses.
- Authors: Rünger TM
- Issue date: 2007 Sep