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    Oxidatively damaged DNA and inflammation in the liver of dyslipidemic ApoE-/- mice exposed to diesel exhaust particles.

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    Authors
    Folkmann, Janne Kjaersgaard
    Risom, Lotte
    Hansen, Christian Stevns
    Loft, Steffen
    Moller, Peter
    Issue Date
    2007-07-31
    
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    Abstract
    Epidemiological studies have shown that exposure to air pollution particles is associated with cardiovascular diseases, whereas the role in the initiation of atherosclerosis is unresolved. Atherosclerosis is considered to be an inflammatory disease that also involves oxidative stress. Here we investigated effects of oxidative stress elicited by diesel exhaust particles (DEP) in the aorta, liver, and lung of dyslipidemic ApoE(-/-) mice at the age when visual plaques appear in the aorta (11-13 weeks). DEP was administrated by intraperitoneal injection (0, 50, 500 and 5,000 microg DEP/kg bodyweight) in order to omit vascular effects secondary to pulmonary inflammation. The mice were killed either 6 or 24h after the administration. Inflammation was measured as the expression of inducible nitric oxide synthase (iNOS) and serum nitric oxide and DNA damage was measured by the comet assay. The expression of iNOS mRNA was increased in the liver 6h after the administration. The level of oxidized purine bases, determined as formamidopyrimidine DNA glycosylase sites was increased by 67% (95% CI: 11-124%) in the liver after 24h in the mice administrated with only 50 microg/kg bodyweight. However, there was no indication of systemic inflammation determined as the serum concentration of nitric oxide and iNOS expression, and DNA damage was not increased in the aorta. These observations indicate that intraperitoneal DEP injection does not induce inflammation or oxidatively damaged DNA in the lung and aorta, whereas a direct effect in terms of inflammation and oxidized DNA was observed in the liver of dyslipidemic ApoE(-/-) mice.
    Citation
    Toxicology 2007, 237 (1-3):134-144
    Journal
    Toxicology
    URI
    http://hdl.handle.net/10146/33859
    DOI
    10.1016/j.tox.2007.05.009
    PubMed ID
    17602821
    Additional Links
    http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCN-4NS2GNG-2&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=57c998f28c592ff59f7a2bee5340b2b4
    Type
    Article
    Language
    en
    ISSN
    0300-483X
    Sponsors
    The work was partly supported by Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No. 513943) and the Danish Research Councils.
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.tox.2007.05.009
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