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dc.contributor.authorReszka, Edyta
dc.contributor.authorPeplonska, Beata
dc.contributor.authorWieczorek, Edyta
dc.contributor.authorSobala, Wojciech
dc.contributor.authorBukowska, Agnieszka
dc.contributor.authorGromadzinska, Jolanta
dc.contributor.authorLie, Jenny-Anne
dc.contributor.authorKjuus, Helge
dc.contributor.authorWasowicz, Wojciech
dc.date.accessioned2014-09-26T10:27:08Zen
dc.date.available2014-09-26T10:27:08Zen
dc.date.issued2013-03-01en
dc.identifier.citationScand J Work Environ Health 2013, 39 (2):178-86en
dc.identifier.issn1795-990Xen
dc.identifier.pmid22517501en
dc.identifier.doi10.5271/sjweh.3299en
dc.identifier.urihttp://hdl.handle.net/10146/331884en
dc.description.abstractPeople living in industrialized societies have developed specific working schedules during the day and at night, including permanent night shifts and rotating night shifts. The aim of this study was to examine the association between circadian polymorphisms and rotating night shift work.
dc.description.abstractThis cross-sectional study comprised 709 nurses and midwives (348 current rotating and 361 current day workers). Genetic polymorphism of selected clock genes BMAL1 (rs2279287), CLOCK (rs1801260), PER1 (rs2735611), PER2 (rs2304672), PER3 (rs10462020), CRY1 (rs8192440), CRY2 (rs10838527, rs10838527) was determined using real-time polymerase chain reaction (PCR) assays.
dc.description.abstractThere were no differences in BMAL1, CLOCK, CRY2, PER1, PER2, and PER3 genotypes among nurses and midwives working rotating night and day shifts. The frequency of women with rare CRY1 TT genotype was higher in the group of rotating night shift than day workers (17.0% versus 13.9%, P=0.06). Moreover, CRY1 TT genotype was associated with the total rotating shift-work duration, compared to women rarely working night shifts.
dc.description.abstractThese results suggest that CRY1 (rs8192440) polymorphism may influence the adaptation to the rotating night shift work among nurses and midwives.
dc.description.sponsorshipThis project was supported by a grant from the Polish- Norwegian Research Fund (PNRF 243-AI-1/07) and ECNIS2 (7PR/2011/266198). The authors declare no actual or potential competing financial interests.en
dc.language.isoenen
dc.relation.urlhttp://www.sjweh.fi/show_abstract.php?abstract_id=3299en
dc.rightsArchived with thanks to Scandinavian journal of work, environment & healthen
dc.subjectCanceren
dc.subjectGenotypeen
dc.subjectNight worken
dc.subjectRotating shiften
dc.subjectShift workeren
dc.subjectNursesen
dc.subjectSleepen
dc.subjectCross-sectional studyen
dc.subject.meshAdaptation, Physiologicalen
dc.subject.meshAdulten
dc.subject.meshCircadian Rhythmen
dc.subject.meshCircadian Rhythm Signaling Peptides and Proteinsen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshMiddle Ageden
dc.subject.meshNursesen
dc.subject.meshPolymorphism, Geneticen
dc.subject.meshWork Schedule Toleranceen
dc.titleRotating night shift work and polymorphism of genes important for the regulation of circadian rhythm.en
dc.typeArticleen
dc.identifier.journalScandinavian Journal of Work, Environment & Healthen
html.description.abstractPeople living in industrialized societies have developed specific working schedules during the day and at night, including permanent night shifts and rotating night shifts. The aim of this study was to examine the association between circadian polymorphisms and rotating night shift work.
html.description.abstractThis cross-sectional study comprised 709 nurses and midwives (348 current rotating and 361 current day workers). Genetic polymorphism of selected clock genes BMAL1 (rs2279287), CLOCK (rs1801260), PER1 (rs2735611), PER2 (rs2304672), PER3 (rs10462020), CRY1 (rs8192440), CRY2 (rs10838527, rs10838527) was determined using real-time polymerase chain reaction (PCR) assays.
html.description.abstractThere were no differences in BMAL1, CLOCK, CRY2, PER1, PER2, and PER3 genotypes among nurses and midwives working rotating night and day shifts. The frequency of women with rare CRY1 TT genotype was higher in the group of rotating night shift than day workers (17.0% versus 13.9%, P=0.06). Moreover, CRY1 TT genotype was associated with the total rotating shift-work duration, compared to women rarely working night shifts.
html.description.abstractThese results suggest that CRY1 (rs8192440) polymorphism may influence the adaptation to the rotating night shift work among nurses and midwives.


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