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dc.contributor.authorCastano-Vinyals, Gemma
dc.contributor.authorTalaska, Glenn
dc.contributor.authorRothman, Nathaniel
dc.contributor.authorAlguacil, Juan
dc.contributor.authorGarcia-Closas, Montserrat
dc.contributor.authorDosemeci, Mustafa
dc.contributor.authorCantor, Kenneth P.
dc.contributor.authorMalats, Nuria
dc.contributor.authorReal, Francisco X.
dc.contributor.authorSilverman, Debra
dc.contributor.authorSerra, Consol
dc.contributor.authorCarrato, Alfredo
dc.contributor.authorTardon, Adonina
dc.contributor.authorGarcia-Closas, Reina
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorVermeulen, Roel
dc.date.accessioned2008-06-23T11:18:45Z
dc.date.available2008-06-23T11:18:45Z
dc.date.issued2007-10
dc.identifier.citationCancer Epidemiol. Biomarkers Prev. 2007, 16 (10):2155-2159en
dc.identifier.issn1055-9965
dc.identifier.pmid17932365
dc.identifier.doi10.1158/1055-9965.EPI-07-0184
dc.identifier.urihttp://hdl.handle.net/10146/30295
dc.description.abstractExposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with risk of bladder cancer and with increased bulky DNA adduct levels in several studies, mainly in smokers. We investigated the relation between bulky PAH-DNA adducts in peripheral blood mononuclear cells and bladder cancer in nonsmoking subjects from a large hospital-based case-control study in Spain. Additionally, we examined the association between DNA adduct formation and several air pollution proxies. The study comprised 76 nonsmoking cases and 76 individually matched controls by sex, region of residence, age, and smoking status (never, former). To maximize the relevance of the DNA adduct measurement as a proxy of PAH exposure, subjects selected had not changed residence, occupation, and major lifestyle factors during the last 10 years. Bulky DNA adducts were measured using the (32)P-postlabeling technique, nuclease P1 treatment. The percentage of detectable adducts was higher in controls (41%) than in cases (32%) with an odds ratio of 0.75 (95% confidence interval, 0.36-1.58). In an analysis limited to controls, a higher percentage of DNA adducts was found among those whose last residence was in a big city (50%) compared with those living in villages (19%; P = 0.04). No consistent associations were found for other markers of air pollution. In this study, among nonsmokers with stable environmental and lifestyle factors, bulky DNA adducts were not associated with bladder cancer risk. Results do not support an association of bladder cancer risk with low-level exposure to PAHs as measured through the formation of bulky DNA adducts in peripheral mononuclear cells.
dc.language.isoenen
dc.relation.urlhttp://cebp.aacrjournals.org/cgi/content/full/16/10/2155en
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAir Pollution
dc.subject.meshCase-Control Studies
dc.subject.meshCross-Sectional Studies
dc.subject.meshDNA Adducts
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPolycyclic Hydrocarbons, Aromatic
dc.subject.meshRisk Factors
dc.subject.meshRural Population
dc.subject.meshSmoking
dc.subject.meshSmoking Cessation
dc.subject.meshSpain
dc.subject.meshUrban Population
dc.subject.meshUrinary Bladder Neoplasms
dc.titleBulky DNA adduct formation and risk of bladder cancer.en
dc.typeArticleen
dc.identifier.journalCancer Epidemiology, Biomarkers & Prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncologyen
html.description.abstractExposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with risk of bladder cancer and with increased bulky DNA adduct levels in several studies, mainly in smokers. We investigated the relation between bulky PAH-DNA adducts in peripheral blood mononuclear cells and bladder cancer in nonsmoking subjects from a large hospital-based case-control study in Spain. Additionally, we examined the association between DNA adduct formation and several air pollution proxies. The study comprised 76 nonsmoking cases and 76 individually matched controls by sex, region of residence, age, and smoking status (never, former). To maximize the relevance of the DNA adduct measurement as a proxy of PAH exposure, subjects selected had not changed residence, occupation, and major lifestyle factors during the last 10 years. Bulky DNA adducts were measured using the (32)P-postlabeling technique, nuclease P1 treatment. The percentage of detectable adducts was higher in controls (41%) than in cases (32%) with an odds ratio of 0.75 (95% confidence interval, 0.36-1.58). In an analysis limited to controls, a higher percentage of DNA adducts was found among those whose last residence was in a big city (50%) compared with those living in villages (19%; P = 0.04). No consistent associations were found for other markers of air pollution. In this study, among nonsmokers with stable environmental and lifestyle factors, bulky DNA adducts were not associated with bladder cancer risk. Results do not support an association of bladder cancer risk with low-level exposure to PAHs as measured through the formation of bulky DNA adducts in peripheral mononuclear cells.


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