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    LC-QTOF/MS metabolomic profiles in human plasma after a 5-week high dietary fiber intake.

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    Authors
    Johansson-Persson, Anna
    Barri, Thaer
    Ulmius, Matilda
    Onning, Gunilla
    Dragsted, Lars Ove
    Issue Date
    2013-05
    
    Metadata
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    Abstract
    The objective was to investigate the alterations of plasma metabolome profiles to identify exposure and effect markers of dietary fiber intake. Subjects (n = 25) aged 58.6 (1.1) years (mean and SD) with a body mass index of 26.6 (0.5) kg/m(2) were given a high fiber (HF) and a low fiber (LF) diet, in a 5-week randomized controlled crossover intervention. The HF diet consisted of oat bran, rye bran, and sugar beet fiber incorporated into test food products, whereas the LF diet was made of equivalent food products to the HF diet, but without adding fibers. Blood plasma samples were collected at the start and end of each intervention period and analyzed by LC-QTOF/MS. In total, 6 features in positive mode and 14 features in negative mode were significantly different between the HF and the LF diet (p < 0.01, q < 0.05). Two markers, 2,6-dihydroxybenzoic acid and 2-aminophenol sulfate, were increased after HF diet, along with a tentatively identified saponin derived from oat avenacosides. The untargeted metabolomics approach enabled the identification of two new markers of dietary fiber intake in human plasma. Further studies will be needed to verify if these markers could serve as compliance markers of fiber intake.
    Citation
    Anal Bioanal Chem 2013, 405 (14):4799-4809
    Journal
    Analytical and Bioanalytical Chemistry
    URI
    http://hdl.handle.net/10146/288554
    DOI
    10.1007/s00216-013-6874-5
    PubMed ID
    23535740
    Additional Links
    http://link.springer.com/article/10.1007%2Fs00216-013-6874-5
    Type
    Article
    Language
    en
    ISSN
    1618-2650
    Sponsors
    This work has been supported by Nordic Centre of Excellence SYSDIET (Systems biology in controlled dietary interventions and cohort studies, no. 070014), OPUS (Optimal wellbeing, development and health for Danish children through a healthy New Nordic Diet, supported by a grant from the Nordea Foundation), the European Network of Excellence NuGO (The European Nutrigenomics Organization), the EU Network of Excellence ECNIS2 (Environmental Cancer Risk , Nutrition and Individual Susceptibility) and a VINNOVA grant (project number 2004–02285). Biomedical Nutrition, Lund University and the Department of Nutrition, Exercise and Sports, University of Copenhagen are members of the NuGO Association.
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00216-013-6874-5
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