Higher leukocyte 8-oxo-7,8-dihydro-2'-deoxyguanosine and lower plasma ascorbate in aging humans?
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Authors
Siomek, AgnieszkaGackowski, Daniel
Rozalski, Rafal
Dziaman, Tomasz
Szpila, Anna
Guz, Jolanta
Olinski, Ryszard
Issue Date
2007-01
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Show full item recordAbstract
Is oxidative damage of DNA responsible for physiological changes associated with aging? The authors note a positive correlation between the age of human subjects with the level of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in leukocyte DNA. The levels of urinary 8-oxo-7,8-dihydroguanine and 8-oxodG followed the same pattern of correlation. Age-dependent decline in the concentration of plasma vitamin C was also evident. These interesting observations in humans point towards the need to scrutinize in detail the role of oxidative DNA damage and compromised antioxidant defense systems in age-related physiological disorders.Citation
Antioxid. Redox Signal. 2007, 9 (1):143-150Journal
Antioxidants & Redox SignalingPubMed ID
17115893Additional Links
http://www.liebertonline.com/doi/abs/10.1089/ars.2007.9.143Type
ArticleLanguage
enISSN
1523-0864ae974a485f413a2113503eed53cd6c53
10.1089/ars.2007.9.143
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