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    Higher leukocyte 8-oxo-7,8-dihydro-2'-deoxyguanosine and lower plasma ascorbate in aging humans?

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    Authors
    Siomek, Agnieszka
    Gackowski, Daniel
    Rozalski, Rafal
    Dziaman, Tomasz
    Szpila, Anna
    Guz, Jolanta
    Olinski, Ryszard
    Issue Date
    2007-01
    
    Metadata
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    Abstract
    Is oxidative damage of DNA responsible for physiological changes associated with aging? The authors note a positive correlation between the age of human subjects with the level of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in leukocyte DNA. The levels of urinary 8-oxo-7,8-dihydroguanine and 8-oxodG followed the same pattern of correlation. Age-dependent decline in the concentration of plasma vitamin C was also evident. These interesting observations in humans point towards the need to scrutinize in detail the role of oxidative DNA damage and compromised antioxidant defense systems in age-related physiological disorders.
    Citation
    Antioxid. Redox Signal. 2007, 9 (1):143-150
    Journal
    Antioxidants & Redox Signaling
    URI
    http://hdl.handle.net/10146/28006
    DOI
    10.1089/ars.2007.9.143
    PubMed ID
    17115893
    Additional Links
    http://www.liebertonline.com/doi/abs/10.1089/ars.2007.9.143
    Type
    Article
    Language
    en
    ISSN
    1523-0864
    ae974a485f413a2113503eed53cd6c53
    10.1089/ars.2007.9.143
    Scopus Count
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