Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations.
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Paolo Ivaldi, Giovanni
Aldo Canessa, Pier
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AbstractThe role of CYP1A1, GSTM1, GSTT1, EPHX1, and NAT2 genotypes in susceptibility to malignant mesothelioma (MM) was compared in two case-control studies, previously conducted in two countries where different types of asbestos fibers have been used [Hirvonen et al., 1995. Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma. Cancer Res. 55, 2981-2983; Hirvonen et al., 1996. Glutathione S-Transferase and N-Acetyltransferase genotypes and asbestos-associated pulmonary disorders. J. Natl. Cancer Inst.88, 1853-1856; Neri et al., 2005. Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure. Mutat. Res. 592, 36-44]. Fifty-seven asbestos-exposed MM patients and 255 controls were recruited in Italy, 48 cases and 121 controls in Finland. In order to make the two studies comparable, they have been updated and new genotyping analyses have been performed. The NAT2 fast acetylator and EPHX1 low-activity genotypes were positively associated with MM in the Italian study, while they were negatively associated with this malignancy in the Finnish one. A combined significant effect was also observed in the Italian study for the NAT2 fast acetylator and EPHX1 low-activity genotypes, while this combination was protective in the Finnish study. Combination of NAT2 fast acetylator and GSTM1 null genotype posed a significantly increased risk of MM in the Italian, but not in the Finnish study. The opposite results obtained in Finland and Italy may be ascribed to random chance, but a role may be hypothesized for the fact that different types of asbestos have been used in the two countries.
CitationInt. J. Hyg. Environ. Health 2006, 209 (4):393-398
SponsorsThis work was supported by the EU funded ECNIS network of excellence, by the Italian Ministry of Health and by “Fondazione ONLUS-Buzzi”. The work of MN was partially supported by AIRC (Italian Association for Cancer Research).
- Pooled analysis of NAT2 genotypes as risk factors for asbestos-related malignant mesothelioma.
- Authors: Betti M, Neri M, Ferrante D, Landi S, Biava A, Gemignani F, Bertolotti M, Mirabelli D, Padoan M, Ugolini D, Botta M, Bonassi S, Magnani C, Dianzani I
- Issue date: 2009 May
- Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders.
- Authors: Hirvonen A, Saarikoski ST, Linnainmaa K, Koskinen K, Husgafvel-Pursiainen K, Mattson K, Vainio H
- Issue date: 1996 Dec 18
- Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma.
- Authors: Hirvonen A, Pelin K, Tammilehto L, Karjalainen A, Mattson K, Linnainmaa K
- Issue date: 1995 Jul 15
- Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure.
- Authors: Neri M, Filiberti R, Taioli E, Garte S, Paracchini V, Bolognesi C, Canessa PA, Fontana V, Ivaldi GP, Verna A, Bonassi S, Puntoni R
- Issue date: 2005 Dec 30
- Genetic susceptibility to malignant pleural mesothelioma and other asbestos-associated diseases.
- Authors: Neri M, Ugolini D, Dianzani I, Gemignani F, Landi S, Cesario A, Magnani C, Mutti L, Puntoni R, Bonassi S
- Issue date: 2008 Jul-Aug