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    DNA and protein adducts in human tissues resulting from exposure to tobacco smoke.

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    Authors
    Phillips, David H.
    Venitt, Stan
    Issue Date
    2012-12-15
    
    Metadata
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    Abstract
    Tobacco smoke contains a variety of genotoxic carcinogens that form adducts with DNA and protein in the tissues of smokers. Not only are these biochemical events relevant to the carcinogenic process, but the detection of adducts provides a means of monitoring exposure to tobacco smoke. Characterization of smoking-related adducts has shed light on the mechanisms of smoking-related diseases and many different types of smoking-derived DNA and protein adducts have been identified. Such approaches also reveal the potential harm of environmental tobacco smoke (ETS) to nonsmokers, infants and children. Because the majority of tobacco-smoke carcinogens are not exclusive to this source of exposure, studies comparing smokers and nonsmokers may be confounded by other environmental sources. Nevertheless, certain DNA and protein adducts have been validated as biomarkers of exposure to tobacco smoke, with continuing applications in the study of ETS exposures, cancer prevention and tobacco product legislation. Our article is a review of the literature on smoking-related adducts in human tissues published since 2002.
    Citation
    Int. J. Cancer 2012, 131 (12):2733-2753
    Journal
    International Journal of Cancer. Journal international du cancer
    URI
    http://hdl.handle.net/10146/269636
    DOI
    10.1002/ijc.27827
    PubMed ID
    22961407
    Additional Links
    http://onlinelibrary.wiley.com/doi/10.1002/ijc.27827/abstract;jsessionid=51C54FA89A9476C2FFF56552F5EFE855.d02t01
    Type
    Article
    Language
    en
    ISSN
    1097-0215
    Sponsors
    Research in the authors’ laboratory is funded, in part, by Cancer Research UK. D.H.P. is a participating partner in the European Union Network of Excellence ECNIS2 (Environmental Cancer Risk, Nutrition and Individual Susceptibility.
    ae974a485f413a2113503eed53cd6c53
    10.1002/ijc.27827
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