Exposure to Polycyclic Aromatic Hydrocarbons Among Never Smokers in Golestan Province, Iran, an Area of High Incidence of Esophageal Cancer - a Cross-Sectional Study with Repeated Measurement of Urinary 1-OHPG in Two Seasons.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Van Schooten, Frederik J.
Phillips, David H.
Fazel-Tabar Malekshah, Akbar
MetadataShow full item record
AbstractStudies have suggested a possible role of polycyclic aromatic hydrocarbons (PAHs) in the etiology of esophageal cancer in Golestan Province, Iran, where incidence of this cancer is very high. In order to investigate the patterns of non-smoking related exposure to PAHs in Golestan, we conducted a cross-sectional study collecting questionnaire data, genotyping polymorphisms related to PAH metabolism, and measuring levels of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite, in urine samples collected in two seasons from the same group of 111 randomly selected never-smoking women. Beta-coefficients for correlations between 1-OHPG as dependent variable and other variables were calculated using linear regression models. The creatinine-adjusted 1-OHPG levels in both winter and summer samples were approximately 110 μmol/molCr (P for seasonal difference = 0.40). In winter, red meat intake (β = 0.208; P = 0.03), processed meat intake (β = 0.218; P = 0.02), and GSTT1-02 polymorphism ("null" genotype: β = 0.228; P = 0.02) showed associations with 1-OHPG levels, while CYP1B1-07 polymorphism (GG versus AA + GA genotypes: β = -0.256; P = 0.008) showed an inverse association. In summer, making bread at home (> weekly versus never: β = 0.203; P = 0.04), second-hand smoke (exposure to ≥3 cigarettes versus no exposure: β = 0.254; P = 0.01), and GSTM1-02 "null" genotype (β = 0.198; P = 0.04) showed associations with 1-OHPG levels, but GSTP1-02 polymorphism (CT + TT versus CC: β = -0.218; P = 0.03) showed an inverse association. This study confirms high exposure of the general population in Golestan to PAHs and suggests that certain foods, cooking methods, and genetic polymorphisms increase exposure to PAHs.
CitationFront. Oncol. 2012, 2:14
JournalFrontiers in Oncology
SponsorsData and sample collection was supported by Digestive Disease Research Center of Tehran University of Medical Sciences and International Agency for Research on Cancer. Laboratory assessments were funded by ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program [Priority 5: “Food Quality and Safety” (Contract No. 513943)].
- Influence of GSTM1 genotype on association between aromatic DNA adducts and urinary PAH metabolites in incineration workers.
- Authors: Lee J, Kang D, Lee KH, Ichiba M, Zhang J, Tomokuni K, Hwang ES, Park CG, Ha M, Kim S, Han SB, Choi JW, Lee E, Jang JY, Strickland PT, Hirvonen A, Cho SH
- Issue date: 2002 Feb 15
- Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil.
- Authors: Fagundes RB, Abnet CC, Strickland PT, Kamangar F, Roth MJ, Taylor PR, Dawsey SM
- Issue date: 2006 May 26
- Association of exposure to polycyclic aromatic hydrocarbons (estimated from job category) with concentration of 1-hydroxypyrene glucuronide in urine from workers at a steel plant.
- Authors: Kang D, Rothman N, Cho SH, Lim HS, Kwon HJ, Kim SM, Schwartz B, Strickland PT
- Issue date: 1995 Sep
- Variations in urinary 1-hydroxypyrene glucuronide in relation to smoking and the modification effects of GSTM1 and GSTT1.
- Authors: Hong YC, Leem JH, Park HS, Lee KH, Lee SJ, Lee CK, Kang D
- Issue date: 1999 Sep 5
- Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women's Health Study.
- Authors: Hofmann JN, Liao LM, Strickland PT, Shu XO, Yang G, Ji BT, Li HL, Rothman N, Kamangar F, Gao YT, Zheng W, Chow WH
- Issue date: 2013 Jun 11