Does measurement of oxidative damage to DNA have clinical significance?
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Issue Date
2006-03
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Oxidative damage to DNA is the seemingly inevitable consequence of cellular metabolism. Furthermore, despite protective mechanisms, cellular levels of damage may increase under conditions of oxidative stress, arising from exposure to a variety of physical or chemical insults. Elevated levels of oxidatively damaged DNA have been measured in numerous diseases, and as a result, it has been hypothesised that such damage plays an integral role in the aetiology of that disease. This review examines the validity of this hypothesis, exploring the mechanisms by which oxidative DNA damage may lead to disease. We conclude that further validation of biomarkers of oxidative DNA damage, along with further elucidation of the role of damage in disease, may allow these biomarkers to become potentially useful clinical tools.Citation
Clin. Chim. Acta 2006, 365 (1-2):30-49PubMed ID
16214123Type
ArticleLanguage
enISSN
0009-8981Sponsors
MSC and MDE gratefully acknowledge financial support from the Food Standards Agency, Leicester Dermatology Research Fund and Arthritis Research Campaign. RO acknowledges financial support from the EU “ECNIS” grant #513943.ae974a485f413a2113503eed53cd6c53
10.1016/j.cca.2005.09.009
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