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    Does measurement of oxidative damage to DNA have clinical significance?

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    Authors
    Cooke, Marcus S.
    Olinski, Ryszard
    Evans, Mark D.
    Issue Date
    2006-03
    
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    Abstract
    Oxidative damage to DNA is the seemingly inevitable consequence of cellular metabolism. Furthermore, despite protective mechanisms, cellular levels of damage may increase under conditions of oxidative stress, arising from exposure to a variety of physical or chemical insults. Elevated levels of oxidatively damaged DNA have been measured in numerous diseases, and as a result, it has been hypothesised that such damage plays an integral role in the aetiology of that disease. This review examines the validity of this hypothesis, exploring the mechanisms by which oxidative DNA damage may lead to disease. We conclude that further validation of biomarkers of oxidative DNA damage, along with further elucidation of the role of damage in disease, may allow these biomarkers to become potentially useful clinical tools.
    Citation
    Clin. Chim. Acta 2006, 365 (1-2):30-49
    Journal
    Clinica chimica acta; international journal of clinical chemistry
    URI
    http://hdl.handle.net/10146/24117
    DOI
    10.1016/j.cca.2005.09.009
    PubMed ID
    16214123
    Additional Links
    http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T57-4H8MP2T-3&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=3fed4a3b0a49b1e9f4b27bbdef6e3694
    Type
    Article
    Language
    en
    ISSN
    0009-8981
    Sponsors
    MSC and MDE gratefully acknowledge financial support from the Food Standards Agency, Leicester Dermatology Research Fund and Arthritis Research Campaign. RO acknowledges financial support from the EU “ECNIS” grant #513943.
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cca.2005.09.009
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