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    Antiproliferative activity of extracts of some Bolivian medicinal plants.

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    Authors
    Rodrigo, Gloria C.
    Almanza, Giovanna R.
    Akesson, Bjorn
    Duan, Rui-Dong
    Issue Date
    2010-11-04
    
    Metadata
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    Abstract
    Twenty-six plant species from the native flora used in Bolivian folk medicine were selected for studies of bioactivity. They belonged to the following families namely: Asteraceae (11), Brassicaceae (1), Cactaceae (1), Caesalpinaceae (2), Chenopodiaceae (1), Frankeniaceae (1), Geraniaceae (1), Laureaceae (1), Oxalidaceae (1), Piperaceae (1), Plantaginaceae (1), Rosaceae (1), Solanaceae (1) and Verbenaceae (2). Their effects on the proliferation of colon cancer cells (Caco-2) were studied using the WST-1 reagent. The results indicated that four out of 26 ethanolic extracts had a significant antiproliferative activity in this assay from (Schkuhria pinnata, Piper longestylosum, Parastrephia lepidophylla and Erodium cicutarium). The bioactivity of the extracts was correlated with the phytochemical characterization. Further studies of the mechanism of action of the bioactive extracts are needed.
    Citation
    J. Med. Plant. Res. 2010, 4:2204-2210
    Journal
    Journal of Medicinal Plants Research
    URI
    http://hdl.handle.net/10146/233171
    Additional Links
    http://www.academicjournals.org/JMPR/abstracts/abstracts/abstracts2010/4Nov/Rodrigo%20et%20al.htm
    Type
    Article
    Language
    en
    ISSN
    1996-0875
    Sponsors
    This research was supported by Swedish International Development Agency (Sida) by funding a joint project on Plant Biodiversity between Major University of San Andres, La Paz, Bolivia and Lund University, Sweden. Some support was obtained from the EU NoE ECNIS (513943).
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