Salvage of oxidized guanine derivatives in the (2'-deoxy)ribonucleotide pool as source of mutations in DNA.
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Issue Date
2010-11-28
Metadata
Show full item recordAbstract
Recent evidence suggests that salvage of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydro-guanine (8-oxoGua) can contribute substantially to levels of 8-oxoGua in DNA and RNA. However, it remains to be determined if this mechanism contributes to mutagenesis and disease. This review covers the predominant methods for detecting 8-oxoGua and its derivatives, summarizes some of the relevant recent DNA repair studies and discusses the mechanisms for metabolism of oxidized guanine derivatives in the (2'-deoxy)ribonucleoside and (2'-deoxy)ribonucleotide pools.Citation
Mutat. Res. 2010, 703 (1):11-17Journal
Mutation ResearchPubMed ID
20833264Additional Links
http://www.sciencedirect.com/science/article/pii/S1383571810003128http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991500/?tool=pubmed
Type
ArticleLanguage
enISSN
0027-5107Sponsors
MSC and MDE are partners of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No. 513943). The laboratories of MSC and MDE are supported by the World Cancer Research Fund, and ECNIS.ae974a485f413a2113503eed53cd6c53
10.1016/j.mrgentox.2010.08.021
Scopus Count
Collections
Related articles
- Urinary measurement of 8-OxodG, 8-OxoGua, and 5HMUra: a noninvasive assessment of oxidative damage to DNA.
- Authors: Olinski R, Rozalski R, Gackowski D, Foksinski M, Siomek A, Cooke MS
- Issue date: 2006 May-Jun
- Oxidative DNA damage in cancer patients: a cause or a consequence of the disease development?
- Authors: Olinski R, Gackowski D, Rozalski R, Foksinski M, Bialkowski K
- Issue date: 2003 Oct 29
- Oxidized guanine lesions as modulators of gene transcription. Altered p50 binding affinity and repair shielding by 7,8-dihydro-8-oxo-2'-deoxyguanosine lesions in the NF-kappaB promoter element.
- Authors: Hailer-Morrison MK, Kotler JM, Martin BD, Sugden KD
- Issue date: 2003 Aug 19
- Oxidative damage DNA: 8-oxoGua and 8-oxodG as molecular markers of cancer.
- Authors: Roszkowski K, Jozwicki W, Blaszczyk P, Mucha-Malecka A, Siomek A
- Issue date: 2011 Jun
- In vitro replication and repair studies of tandem lesions containing neighboring thymidine glycol and 8-oxo-7,8-dihydro-2'-deoxyguanosine.
- Authors: Jiang Y, Wang Y, Wang Y
- Issue date: 2009 Mar 16