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    Salvage of oxidized guanine derivatives in the (2'-deoxy)ribonucleotide pool as source of mutations in DNA.

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    Authors
    Henderson, Paul T.
    Evans, Mark D.
    Cooke, Marcus S.
    Issue Date
    2010-11-28
    
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    Abstract
    Recent evidence suggests that salvage of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydro-guanine (8-oxoGua) can contribute substantially to levels of 8-oxoGua in DNA and RNA. However, it remains to be determined if this mechanism contributes to mutagenesis and disease. This review covers the predominant methods for detecting 8-oxoGua and its derivatives, summarizes some of the relevant recent DNA repair studies and discusses the mechanisms for metabolism of oxidized guanine derivatives in the (2'-deoxy)ribonucleoside and (2'-deoxy)ribonucleotide pools.
    Citation
    Mutat. Res. 2010, 703 (1):11-17
    Journal
    Mutation Research
    URI
    http://hdl.handle.net/10146/232171
    DOI
    10.1016/j.mrgentox.2010.08.021
    PubMed ID
    20833264
    Additional Links
    http://www.sciencedirect.com/science/article/pii/S1383571810003128
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991500/?tool=pubmed
    Type
    Article
    Language
    en
    ISSN
    0027-5107
    Sponsors
    MSC and MDE are partners of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No. 513943). The laboratories of MSC and MDE are supported by the World Cancer Research Fund, and ECNIS.
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.mrgentox.2010.08.021
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