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dc.contributor.authorRodrigo, Gloria
dc.contributor.authorAlmanza, Giovanna R.
dc.contributor.authorCheng, Yajun
dc.contributor.authorPeng, Jiangnan
dc.contributor.authorHamann, Mark
dc.contributor.authorDuan, Rui-Dong
dc.contributor.authorAkesson, Bjorn
dc.date.accessioned2012-07-04T10:14:40Z
dc.date.available2012-07-04T10:14:40Z
dc.date.issued2010-10
dc.identifier.citationFitoterapia 2010, 81 (7):762-766en_GB
dc.identifier.issn1873-6971
dc.identifier.pmid20385210
dc.identifier.doi10.1016/j.fitote.2010.04.001
dc.identifier.urihttp://hdl.handle.net/10146/232072
dc.description.abstractCurcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116 µg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.
dc.description.sponsorshipThis research was supported by the Swedish International Development Agency (Sida) for a project on Plant biodiversity as a collaboration between University Major of San Andres, La Paz, Bolivia and Lund University, Sweden. Lund University is a member of the EU NoE ECNIS, which partly supported the study.en_GB
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0367326X10000791en_GB
dc.rightsArchived with thanks to Fitoterapiaen_GB
dc.subjectCurcuphenolen_GB
dc.subjectCell proliferationen_GB
dc.subjectApoptosisen_GB
dc.subjectDNA replicationen_GB
dc.subjectCaspaseen_GB
dc.subjectPlant Extractsen_GB
dc.subjectAntineoplastic Agentsen_GB
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents, Phytogenic
dc.subject.meshApoptosis
dc.subject.meshBaccharis
dc.subject.meshCaco-2 Cells
dc.subject.meshCaspase 3
dc.subject.meshCell Proliferation
dc.subject.meshColonic Neoplasms
dc.subject.meshDNA Replication
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshHumans
dc.subject.meshPhytotherapy
dc.subject.meshPlant Extracts
dc.subject.meshPorifera
dc.subject.meshSesquiterpenes
dc.titleAntiproliferative effects of curcuphenol, a sesquiterpene phenol.en
dc.typeArticleen
dc.identifier.journalFitoterapiaen_GB
html.description.abstractCurcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116 µg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.


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