DNA damage in salivary gland tissue in patients with chronic kidney disease, measured by the comet assay.
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AbstractThe aim of this observational study was to investigate the relationship between DNA damage in minor accessory salivary glands, hyposalivation, and inflammation in patients with chronic kidney disease (CKD).
DNA strand breaks and oxidative DNA lesions in salivary glands, inflammatory markers, and uremic state were measured in 79 patients with CKD and matched controls.
CKD patients not yet on dialysis had significantly more, and dialysis patients significantly less, DNA strand breaks in salivary tissue compared with controls. All measured inflammatory markers were higher in patients with CKD compared with controls. Salivary secretion rates were significantly lower in dialysis patients compared with controls. A high level of salivary secretion rate at rest significantly predicted a high level of DNA strand breaks in patients with CKD.
Dialysis patients had fewer DNA strand breaks in minor accessory salivary glands than controls, suggesting that peripheral tissue is differently affected by CKD than leukocytes.
CitationOral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2011, 112 (2):209-215
SponsorsThis work was supported by ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No 513,943) and The Swedish Kidney Association.
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