• Login
    View Item 
    •   Home
    • ECNIS - Environmental Cancer Risk, Nutrition and Individual Susceptibility
    • Articles
    • View Item
    •   Home
    • ECNIS - Environmental Cancer Risk, Nutrition and Individual Susceptibility
    • Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ECNIS-NIOMCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsSubject (MeSH)PublisherJournalDepartmentThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsSubject (MeSH)PublisherJournalDepartment

    My Account

    LoginRegister

    External Links

    NIOMNIOMProjectsSherpa/RoMEO

    Statistics

    Display statistics

    European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Authors
    Rafnar, Thorunn
    Vermeulen, Sita H.
    Sulem, Patrick
    Thorleifsson, Gudmar
    Aben, Katja K.H.
    Witjes, J. Alfred
    Grotenhuis, Anne J.
    Verhaegh, Gerald W.
    Hulsbergen-van de Kaa, Christina A.
    Besenbacher, Soren
    Gudbjartsson, Daniel
    Stacey, Simon N.
    Gudmundsson, Julius
    Johannsdottir, Hrefna
    Bjarnason, Hjordis
    Zanon, Carlo
    Helgadottir, Hafdis
    Jonasson, Jon Gunnlaugur
    Tryggvadottir, Laufey
    Jonsson, Eirikur
    Geirsson, Gudmundur
    Nikulasson, Sigfus
    Petursdottir, Vigdis
    Bishop, D. Timothy
    Chung-Sak, Sei
    Choudhury, Ananya
    Elliott, Faye
    Barrett, Jennifer H.
    Knowles, Margaret A.
    de Verdier, Petra J.
    Ryk, Charlotta
    Lindblom, Annika
    Rudnai, Peter
    Gurzau, Eugene
    Koppova, Kvetoslava
    Vineis, Paolo
    Polidoro, Silvia
    Guarrera, Simonetta
    Sacerdote, Carlotta
    Panadero, Angeles
    Sanz-Velez, José I.
    Sanchez, Manuel
    Valdivia, Gabriel
    Garcia-Prats, Maria D.
    Hengstler, Jan G.
    Selinski, Silvia
    Gerullis, Holger
    Ovsiannikov, Daniel
    Khezri, Abdolaziz
    Aminsharifi, Alireza
    Malekzadeh, Mahyar
    van den Berg, Leonard H.
    Ophoff, Roel A.
    Veldink, Jan H.
    Zeegers, Maurice P.
    Kellen, Eliane
    Fostinelli, Jacopo
    Andreoli, Daniele
    Arici, Cecilia
    Porru, Stefano
    Buntinx, Frank
    Ghaderi, Abbas
    Golka, Klaus
    Mayordomo, José I.
    Matullo, Giuseppe
    Kumar, Rajiv
    Steineck, Gunnar
    Kiltie, Anne E.
    Kong, Augustine
    Thorsteinsdottir, Unnur
    Stefansson, Kari
    Kiemeney, Lambertus A.
    Issue Date
    2011-11-01
    
    Metadata
    Show full item record
    Abstract
    Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European GWAS. The discovery sample set consisted of 1631 cases and 3822 controls from the Netherlands and 603 cases and 37 781 controls from Iceland. For follow-up, we used 3790 cases and 7507 controls from 13 sample sets of European and Iranian ancestry. Based on the discovery analysis, we followed up signals in the urea transporter (UT) gene SLC14A. The strongest signal at this locus was represented by a SNP in intron 3, rs17674580, that reached genome-wide significance in the overall analysis of the discovery and follow-up groups: odds ratio = 1.17, P = 7.6 × 10(-11). SLC14A1 codes for UTs that define the Kidd blood group and are crucial for the maintenance of a constant urea concentration gradient in the renal medulla and, through this, the kidney's ability to concentrate urine. It is speculated that rs17674580, or other sequence variants in LD with it, indirectly modifies UBC risk by affecting urine production. If confirmed, this would support the 'urogenous contact hypothesis' that urine production and voiding frequency modify the risk of UBC.
    Citation
    Hum. Mol. Genet. 2011, 20 (21):4268-4281
    Journal
    Human Molecular Genetics
    URI
    http://hdl.handle.net/10146/196490
    DOI
    10.1093/hmg/ddr303
    PubMed ID
    21750109
    Additional Links
    http://hmg.oxfordjournals.org/content/20/21/4268.long
    Type
    Article
    Language
    en
    ISSN
    1460-2083
    Sponsors
    This work was supported by the following funding agencies.Torino Bladder Cancer Case Control Study was supported by a grant to ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: ‘Food Quality and Safety’ (Contract No. 513943); by a grant of the Compagnia di San Paolo—Human Genetics Foundation (HuGeF), the Italian Association for Cancer Research, Italy and the Piedmont Region Progetti di Ricerca Sanitaria Finalizzata.
    ae974a485f413a2113503eed53cd6c53
    10.1093/hmg/ddr303
    Scopus Count
    Collections
    Articles

    entitlement

    Related articles

    • A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3.
    • Authors: Garcia-Closas M, Ye Y, Rothman N, Figueroa JD, Malats N, Dinney CP, Chatterjee N, Prokunina-Olsson L, Wang Z, Lin J, Real FX, Jacobs KB, Baris D, Thun M, De Vivo I, Albanes D, Purdue MP, Kogevinas M, Kamat AM, Lerner SP, Grossman HB, Gu J, Pu X, Hutchinson A, Fu YP, Burdett L, Yeager M, Tang W, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G Jr, Grubb R 3rd, Black A, Jacobs EJ, Diver WR, Gapstur SM, Weinstein SJ, Virtamo J, Hunter DJ, Caporaso N, Landi MT, Fraumeni JF Jr, Silverman DT, Chanock SJ, Wu X
    • Issue date: 2011 Nov 1
    • Replicative study of GWAS TP63C/T, TERTC/T, and SLC14A1C/T with susceptibility to bladder cancer in North Indians.
    • Authors: Singh V, Jaiswal PK, Mittal RD
    • Issue date: 2014 Nov
    • Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer.
    • Authors: Rafnar T, Sulem P, Thorleifsson G, Vermeulen SH, Helgason H, Saemundsdottir J, Gudjonsson SA, Sigurdsson A, Stacey SN, Gudmundsson J, Johannsdottir H, Alexiusdottir K, Petursdottir V, Nikulasson S, Geirsson G, Jonsson T, Aben KK, Grotenhuis AJ, Verhaegh GW, Dudek AM, Witjes JA, van der Heijden AG, Vrieling A, Galesloot TE, De Juan A, Panadero A, Rivera F, Hurst C, Bishop DT, Sak SC, Choudhury A, Teo MT, Arici C, Carta A, Toninelli E, de Verdier P, Rudnai P, Gurzau E, Koppova K, van der Keur KA, Lurkin I, Goossens M, Kellen E, Guarrera S, Russo A, Critelli R, Sacerdote C, Vineis P, Krucker C, Zeegers MP, Gerullis H, Ovsiannikov D, Volkert F, Hengstler JG, Selinski S, Magnusson OT, Masson G, Kong A, Gudbjartsson D, Lindblom A, Zwarthoff E, Porru S, Golka K, Buntinx F, Matullo G, Kumar R, Mayordomo JI, Steineck DG, Kiltie AE, Jonsson E, Radvanyi F, Knowles MA, Thorsteinsdottir U, Kiemeney LA, Stefansson K
    • Issue date: 2014 Oct 15
    • Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry.
    • Authors: Figueroa JD, Middlebrooks CD, Banday AR, Ye Y, Garcia-Closas M, Chatterjee N, Koutros S, Kiemeney LA, Rafnar T, Bishop T, Furberg H, Matullo G, Golka K, Gago-Dominguez M, Taylor JA, Fletcher T, Siddiq A, Cortessis VK, Kooperberg C, Cussenot O, Benhamou S, Prescott J, Porru S, Dinney CP, Malats N, Baris D, Purdue MP, Jacobs EJ, Albanes D, Wang Z, Chung CC, Vermeulen SH, Aben KK, Galesloot TE, Thorleifsson G, Sulem P, Stefansson K, Kiltie AE, Harland M, Teo M, Offit K, Vijai J, Bajorin D, Kopp R, Fiorito G, Guarrera S, Sacerdote C, Selinski S, Hengstler JG, Gerullis H, Ovsiannikov D, Blaszkewicz M, Castelao JE, Calaza M, Martinez ME, Cordeiro P, Xu Z, Panduri V, Kumar R, Gurzau E, Koppova K, Bueno-De-Mesquita HB, Ljungberg B, Clavel-Chapelon F, Weiderpass E, Krogh V, Dorronsoro M, Travis RC, Tjønneland A, Brennan P, Chang-Claude J, Riboli E, Conti D, Stern MC, Pike MC, Van Den Berg D, Yuan JM, Hohensee C, Jeppson RP, Cancel-Tassin G, Roupret M, Comperat E, Turman C, De Vivo I, Giovannucci E, Hunter DJ, Kraft P, Lindstrom S, Carta A, Pavanello S, Arici C, Mastrangelo G, Kamat AM, Zhang L, Gong Y, Pu X, Hutchinson A, Burdett L, Wheeler WA, Karagas MR, Johnson A, Schned A, Monawar Hosain GM, Schwenn M, Kogevinas M, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Andriole G Jr, Grubb R 3rd, Black A, Diver WR, Gapstur SM, Weinstein S, Virtamo J, Haiman CA, Landi MT, Caporaso NE, Fraumeni JF Jr, Vineis P, Wu X, Chanock SJ, Silverman DT, Prokunina-Olsson L, Rothman N
    • Issue date: 2016 Mar 15
    • Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer.
    • Authors: Selinski S, Blaszkewicz M, Ickstadt K, Gerullis H, Otto T, Roth E, Volkert F, Ovsiannikov D, Moormann O, Banfi G, Nyirady P, Vermeulen SH, Garcia-Closas M, Figueroa JD, Johnson A, Karagas MR, Kogevinas M, Malats N, Schwenn M, Silverman DT, Koutros S, Rothman N, Kiemeney LA, Hengstler JG, Golka K
    • Issue date: 2017 Dec 7

    DSpace software (copyright © 2002 - 2019)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.