Assessment of cumulative evidence on genetic associations: interim guidelines.
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AuthorsIoannidis, John P.A
O'Brien, Thomas R.
Uitterlinden, Andre G.
Balding, David J.
Dolan, Siobhan M.
Flanders, W Dana
Higgins, Julian P.T
McCarthy, Mark I.
McDermott, David H.
Page, Grier P.
Rebbeck, Timothy R.
Khoury, Muin J.
MetadataShow full item record
AbstractEstablished guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semi-quantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generates a composite assessment of 'strong', 'moderate' or 'weak' epidemiological credibility. In addition, we discuss how additional input and guidance can be derived from biological data. Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors.
CitationInt J Epidemiol 2008, 37 (1):120-32.
PublisherOxford University Press
SponsorsThis work was partly supported by ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program (Contract No 513943). This research was also supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics and National Institute of Allergy and Infectious Diseases, Laboratory of Molecular Immunology. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.
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